Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BUTYRATE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet.
No AI portrait yet
| Name | BUTYRATE |
graph TD
BUTYRATE["BUTYRATE"]
BUTYRATE -->|"activates"| Intestinal_Epithelial_Cells["Intestinal Epithelial Cells"]
BUTYRATE -->|"inhibits"| HISTONE_DEACETYLASE["HISTONE DEACETYLASE"]
BUTYRATE -->|"inhibits"| HDAC["HDAC"]
BUTYRATE -->|"maintains"| INTESTINAL_BARRIER["INTESTINAL_BARRIER"]
BUTYRATE -->|"produced_by"| FAECALIBACTERIUM["FAECALIBACTERIUM"]
BUTYRATE -.protects against.-> Blood_Brain_Barrier_Integrity["Blood-Brain Barrier Integrity"]
BUTYRATE -->|"involved_in"| Gut_Brain_Communication["Gut-Brain Communication"]| Target | Relation | Type | Str |
|---|---|---|---|
| Cognitive Impairment | treats | phenotype | 0.95 |
| Intestinal Epithelial Cells | activates | cell_type | 0.95 |
| HISTONE DEACETYLASE | inhibits | enzyme | 0.95 |
| Multiorgan Dysfunction | treats | phenotype | 0.90 |
| Tight Junction Protein Formation | associated_with | process | 0.90 |
| BDNF | upregulates | protein | 0.90 |
| Quinolinic Acid-Induced Cognitive Decline | protects_against | phenotype | 0.90 |
| Intestinal Epithelial Cells | associated_with | cell_type | 0.90 |
| Intestinal Epithelial Cell | expressed_in | cell_type | 0.85 |
| Histone Acylation | modulates | process | 0.85 |
| Lifespan | associated_with | phenotype | 0.85 |
| Blood-Brain Barrier Integrity | protects_against | phenotype | 0.85 |
| Gut-Brain Communication | involved_in | pathway | 0.85 |
| H3K18Ac | upregulates | biomarker | 0.85 |
| Intestinal Epithelial Cells | expressed_in | cell_type | 0.80 |
| Neurodegeneration | protects_against | phenotype | 0.80 |
| Brain Trauma Recovery | treats | phenotype | 0.80 |
| Brain Trauma Recovery | associated_with | phenotype | 0.80 |
| Intestinal Barrier Disruption | treats | phenotype | 0.80 |
| Dementia | treats | disease | 0.75 |
| gut barrier integrity | associated_with | phenotype | 0.75 |
| GPR41 | activates | gene | 0.70 |
| Brain Trauma | associated_with | disease | 0.70 |
| BDNF | activates | protein | 0.70 |
| cognitive impairment | protects_against | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Gut Dysbiosis | associated_with | phenotype | 0.90 |
| Microbiota | associated_with | cell_type | 0.90 |
| Tributyrin | associated_with | drug | 0.90 |
| Prevotellaceae | produces | microbiome | 0.90 |
| Intestinal Barrier Disruption | associated_with | phenotype | 0.85 |
| Herba Patriniae With Probiotics | upregulates | drug | 0.85 |
| Gut Dysbiosis | downregulates | phenotype | 0.80 |
| Faecalibacterium prausnitzii | promotes | drug | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Beta-Hydroxybutyrate Receptor (HCAR2) Signaling Links Ketone | 0.808 | neurodegeneration | What are the precise temporal dynamics o |
| Gut-BBB Axis: Tributyrin/Butyrate HDAC Inhibition Epigenetic | 0.712 | - | Blood-brain barrier permeability changes |
| Targeted Butyrate Supplementation for Microglial Phenotype M | 0.700 | neurodegeneration | What are the mechanisms by which gut mic |
| Butyrate-Producing Commensal Depletion Creates Vicious Cycle | 0.630 | neurodegeneration | How does gut microbiome dysbiosis contri |
| Propionate may outperform acetate or butyrate at physiologic | 0.440 | neurodegeneration | Do physiological concentrations of SCFAs |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-11 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| GPR109A receptor validation using knockout macrophages | exploratory | Mycoplasma pneumoniae pneumoni | 0.920 | 0.00 | GPR109A knockout mouse macroph | proposed | N/A |
| Periodontitis-induced colonic inflammation in mice | validation | Periodontitis and intestinal i | 0.900 | 0.00 | C57BL/6J mice | proposed | N/A |
| Fecal microbiota transplantation from periodontitis donors | validation | Periodontitis-associated gut d | 0.900 | 0.00 | Germ-free mice with fecal micr | proposed | N/A |
| GPR109A functional modulation with pharmacological agents | validation | Periodontitis with intestinal | 0.880 | 0.00 | C57BL/6J mice with ligature-in | proposed | N/A |
| Probiotic CBM588 supplementation rescue experiment | validation | Periodontitis-associated intes | 0.850 | 0.00 | C57BL/6J mice with periodontit | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| GPR109a-AMPK axis mediates the Attenuation of uric acid-induced M1 macrophage po [PMID:41882026] | Du M, He Y, Zhu Y, Chen W, Chen X, Yang | Scientific reports | 2026 | 0 |
| Gut microbiota-derived isovaleric acid alleviates atrial fibrillation by suppres [PMID:41638192] | Ding N, Wu H, Hua Y, Hua R, Li B, Xie Y, | Cell metabolism | 2026 | 0 |
| Therapeutic strategies for hypertension: exploring the role of microbiota-derive [PMID:40637840] | Tortelote GG | Pediatr Nephrol | 2026 | 0 |
| Xin-Jia-Tong-Xie-Yao-Fang restores the intestinal barrier to alleviate irritable [PMID:41655800] | Zhu J, Yang L, Fang Z, Chen J, Fu R, Liu | Microbial pathogenesis | 2026 | 0 |
| Cranberry extract-supplemented microbiota effluents enhance intestinal barrier i [PMID:41680408] | Cattero V, Mayer T, Veilleux A, Roussel | Scientific reports | 2026 | 0 |
| Qingfei Tongluo Jiedu Formula Regulates M2 Macrophage Polarization via the Butyr [PMID:41754753] | Liu Z, Fan Q, Sun R, Jiang Y | Pharmaceuticals (Basel, Switze | 2026 | 0 |
| Periodontitis promotes intestinal inflammation through gut microbiota-mediated s [PMID:41816355] | Wang X, Xu Z, Yao Y, Jia H, Du M, Wang S | Frontiers in cellular and infe | 2026 | 0 |
| Hydroxycarboxylic acid receptor 2 (GPR109A) and retinopathies: pathways and pros [PMID:41889514] | Lester J, Amamoo R, Thounaojam MC, Marti | Frontiers in medicine | 2026 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Exercise-induced β-hydroxybutyrate contributes to cognitive improvement in aging [PMID:41421649] | Wang L, Mao L, Zhu D, Li K, Gao H, Zhou | Journal of sport and health sc | 2025 | 0 |
| Chaperone-mediated autophagy, heat shock protein 70, and serotonin: novel target [PMID:40319428] | ["Mohamed R", "Abdallah D", "El-Abhar H" | Inflammopharmacology | 2025 | 0 |
| Not Just an Alternative Energy Source: Diverse Biological Functions of Ketone Bo [PMID:40305364] | Suresh VV, Sivaprakasam S, Bhutia YD, Pr | Biomolecules | 2025 | 0 |
| β-Hydroxybutyrate Regulates Activated Microglia to Alleviate Neurodegenerative P [PMID:36771231] | Jayashankar SS, Tajul Arifin K, Nasarudd | Nutrients | 2023 | 0 |
| Bacterial factors required for Streptococcus pneumoniae coinfection with influen [PMID:34452635] | Chen YY, Huang CT, Li SW, Pan YJ, Lin TL | Journal of biomedical science | 2021 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Face masks considerably reduce COVID-19 cases in Germany. [PMID:33273115] | Mitze T, Kosfeld R, Rode J, Wälde K | Proceedings of the National Ac | 2020 | 0 |
| Serum neuronal exosomes predict and differentiate Parkinson's disease from atypi [PMID:32273329] | Jiang C, Hopfner F, Katsikoudi A, Hein R | Journal of neurology, neurosur | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Adapting Drosophila melanogaster Cell Lines to Serum-Free Culture Conditions. [PMID:33028628] | Luhur A, Mariyappa D, Klueg KM, Buddika | G3 (Bethesda, Md.) | 2020 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning BUTYRATE in their description or question text
No additional research found