gene

ADAM8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ADAM8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

77Connections

0Hypotheses

0Analyses

50Outgoing

12Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ADAM8
Full Name	A Disintegrin And Metalloproteinase Domain 8
Chromosome	10q26.3
Function	is a member of the ADAM (A Disintegrin And Metalloproteinase) family of zinc-dependent metalloproteases.
Primary Expression	immune cells and in the brain, particularly in microglia, astrocytes, and neurons
Amino Acids	833 aa
UniProt ID	[O43506](https://www.uniprot.org/uniprot/O43506)
Ensembl ID	ENSG00000151617
GeneCards	ADAM8
Human Protein Atlas	ADAM8
Zinc-binding site	Essential for proteolytic activity
Active site	HExGHxxGxxH consensus sequence coordinating zinc ion
Substrate-binding groove	Determines substrate specificity
Autocatalytic cleavage	Prodomain removal activates the protease
Furin-mediated processing	Furin-like convertases in the secretory pathway
Associated Diseases	Cancer, Leukemia, Lung Cancer
Interactions	AND, ANXA2, APOPTOSIS, AUTOPHAGY, BAX, BAX/BCL2
KG Connections	76 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ADAM8 Gene

gene · 1509 words

→

ADAM8 Protein

protein · 563 words

→

Pathway Diagram

graph TD
    ADAM8["ADAM8"] -->|"regulates"| Macrophage_Function["Macrophage Function"]
    style Macrophage_Function fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    ADAM8["ADAM8"] -->|"binds"| ANXA2["ANXA2"]
    style ANXA2 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ADAM8["ADAM8"] -.->|"inhibits"| Cardiac_Repair["Cardiac Repair"]
    style Cardiac_Repair fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    ADAM8["ADAM8"] -->|"expressed in"| Cardiac_Macrophages["Cardiac Macrophages"]
    style Cardiac_Macrophages fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ADAM8["ADAM8"] -->|"biomarker for"| Acute_Myocardial_Infarction["Acute Myocardial Infarction"]
    style Acute_Myocardial_Infarction fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ADAM8["ADAM8"] -->|"associated"| Cardiac_Fibrosis["Cardiac Fibrosis"]
    style Cardiac_Fibrosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    ADAM8["ADAM8"] -->|"contributes to"| Inflammation["Inflammation"]
    style Inflammation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    P62["P62"] -->|"activates"| ADAM8["ADAM8"]
    style P62 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    MTOR["MTOR"] -->|"activates"| ADAM8["ADAM8"]
    style MTOR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    INFLAMMATION["INFLAMMATION"] -.->|"inhibits"| ADAM8["ADAM8"]
    style INFLAMMATION fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    BAX["BAX"] -.->|"inhibits"| ADAM8["ADAM8"]
    style BAX fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    APOPTOSIS["APOPTOSIS"] -.->|"inhibits"| ADAM8["ADAM8"]
    style APOPTOSIS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style ADAM8 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (65)

Target	Relation	Type	Str
ANXA2	binds	protein	0.95
Macrophage Function	regulates	process	0.95
Cardiac Repair	inhibits	process	0.90
Acute Myocardial Infarction	biomarker_for	disease	0.90
Cardiac Macrophages	expressed_in	cell_type	0.90
Acute Myocardial Infarction	biomarker_for	disease	0.90
ANXA2	phosphorylates	protein	0.90
Inflammation	contributes_to	process	0.85
Cardiac Fibrosis	associated_with	process	0.85
Cardiac	activates	disease	0.75
macrophages	expressed_in	cell_type	0.72
ANXA2	interacts_with	protein	0.72
Cardiovascular	regulates	disease	0.65
Lung Cancer	associated_with	disease	0.65
Leukemia	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Sepsis	activates	disease	0.65
Inflammation	regulates	disease	0.65
Fibrosis	inhibits	disease	0.65
Ms	activates	disease	0.65
Inflammation	inhibits	disease	0.65
autophagy_pathway	inhibits	pathway	0.64
MERTK	activates	gene	0.60
AND	activates	gene	0.60
Macrophage	activates	cell_type	0.60
Metalloproteinase	regulates	protein	0.60
oxidative stress response	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
Mtor	activates	pathway	0.60
MTOR	activates	gene	0.60
ANXA2	activates	gene	0.60
P62	activates	gene	0.60
RNA	activates	gene	0.60
MTOR	phosphorylates	entity	0.60
ANXA2	regulates	entity	0.60
MTOR	regulates	entity	0.60
Autophagy	activates	pathway	0.60
Angiogenesis	inhibits	pathway	0.60
AUTOPHAGY	activates	gene	0.60
INFLAMMATION	inhibits	gene	0.60
BAX/BCL2	inhibits	gene	0.60
Apoptosis	inhibits	pathway	0.60
cardiac_fibrosis	activates	phenotype	0.56
Macrophage	expressed_in	cell_type	0.55
Myocardial Infarction	expressed_in	disease	0.50
mTOR	activates	entity	0.50
MACROPHAGES	expressed_in	concept	0.50
Cardiac	expressed_in	disease	0.50
Myocardial Infarction	inhibits	disease	0.50
Macrophage	inhibits	cell_type	0.50

Incoming (12)

Source	Relation	Type	Str
RNA	activates	gene	0.60
P62	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
MTOR	activates	gene	0.60
TNFRSF1B	associated_with	gene	0.60
ANXA2	activates	gene	0.60
INFLAMMATION	inhibits	gene	0.60
CANCER	associated_with	gene	0.60
BAX	inhibits	gene	0.60
BCL2	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
INFLAMMATION	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ADAM8 in their description or question text

No additional research found