gene 2,621 words KG: MERTK
Contents

MERTK - MER Tyrosine Kinase

🧬 Gene Info
Gene SymbolMERTK
Full NameMERTK - MER Tyrosine Kinase
AliasesPage for MERTK Protein
Chromosome2q14.1
Protein TypeGene
Primary Expressionmacrophages, microglia, photoreceptor cells, and neurons, where it mediates the clearance of apoptotic cells and cellular debris through recognition o
Molecular Weight110 kDa
Amino Acids998 aa
Exons20
PathwaysNF-κB, PI3K, MAPK
UniProt IDQ12866
NCBI Gene ID10488
Ensembl IDENSG00000153208
GeneCardsMERTK
Human Protein AtlasMERTK
Associated DiseasesAging, Alzheimer, Diabetes, Fibrosis, Hepatitis, Infection
Known Drugs/CompoundsFc-DN30, HDAC Inhibitors
InteractionsADAM8, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, Amyloid-Beta
KG Connections262 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (7)

APOE-Dependent Autophagy Restoration
Score: 0.89
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Complement C1q Mimetic Decoy Therapy
Score: 0.69
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.68
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Complement C1q Subtype Switching
Score: 0.66
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (4)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

Astrocytes
cell · KG edge: activates
ATP P2X3 Receptor Neurons
cell · KG edge: activates
blarcamesine-axon
clinical_trial · KG edge: inhibits
Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates

Knowledge Graph (12 edges)

STAT6 expressed_in MERTK
EPHA4 expressed_in MERTK
MTOR activates MERTK
MERTK activates AKT
MERTK activates MAF
MERTK expressed_in GFAP
MERTK expressed_in ALDH1L1
MERTK expressed_in STAT6
MERTK expressed_in EPHA4
BAX activates MERTK

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