gene

RPN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RPN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections

0Hypotheses

0Analyses

15Outgoing

7Incoming

0Experiments

0Debates

Summary

RPN2 is a gene implicated in neurodegeneration research. Key relationships include: activates, interacts with, implicated in. Associated with ALS, Als, Cancer. Connected to 12 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RPN2
Full Name	Ribophorin II (RPN2)
Chromosome	20q13.33
Function	RPN2 participates in several essential cellular processes:
Primary Expression	Primarily ER membrane
Subcellular Localization	Primarily ER membrane
Molecular Weight	69 kDa
Amino Acids	631 aa
UniProt ID	[P04818](https://www.uniprot.org/uniprot/P04818)
Ensembl ID	ENSG00000120903
GeneCards	RPN2
Human Protein Atlas	RPN2
OST catalytic site	Interacts with the STT3A or STT3B catalytic subunits
Substrate recognition region	Binds nascent polypeptide chains
Multiple glycosylation sites	RPN2 itself is glycosylated
Associated Diseases	cancer
Interactions	ADRA2A, BCL-2, CANCER, CTSD, INFLAMMATION, MAOA
KG Connections	22 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RPN2 Gene

gene · 742 words

→

Pathway Diagram

graph TD
    RPN2["RPN2"]
    Als{"Als"}
    RPN2 -->|"interacts with"| Als
    ALS{"ALS"}
    RPN2 -->|"interacts with"| ALS
    Proteasome(["Proteasome"])
    RPN2 -->|"interacts with"| Proteasome
    RPN2 -->|"associated with"| Proteasome
    neurodegeneration["neurodegeneration"]
    RPN2 -->|"implicated in"| neurodegeneration
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"interacts with"| RPN2
    AND["AND"]
    AND -->|"interacts with"| RPN2
    style RPN2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (15)

Target	Relation	Type	Str
19S COMPLEX	component_of	protein	0.90
Cancer	activates	disease	0.65
Inflammation	activates	disease	0.65
Als	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
RPN1	activates	gene	0.60
Proteasome	associated_with	pathway	0.60
Rb	interacts_with	protein	0.60
cancer	activates	disease	0.60
cancer	causes	disease	0.60
BCL-2	activates	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
Proteasome	interacts_with	pathway	0.60
INFLAMMATION	activates	gene	0.60
CANCER	activates	gene	0.60

Incoming (7)

Source	Relation	Type	Str
ADRM1	binds	protein	0.90
ADRA2A	activates	gene	0.60
CTSD	activates	gene	0.60
MAOA	activates	gene	0.60
ADRA2A	causes	gene	0.60
MAOA	causes	gene	0.60
UBIQUITIN	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RPN2 in their description or question text

No additional research found