gene

gabra2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about gabra2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

68Connections

0Hypotheses

0Analyses

41Outgoing

27Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	GABRA2
Full Name	Gamma-Aminobutyric Acid Type A Receptor Alpha 2 Subunit
Chromosome	4p12
Protein Type	Receptor
Function	encodes a critical subunit of the GABA-A receptor, the primary inhibitory neurotransmitter receptor in the mammalian brain.
Primary Expression	the amygdala, a brain region critical for emotional processing and fear responses
Subcellular Localization	, and functional characteristics, and the alpha2 subunit confers distinct properties that are crucial for understanding
Molecular Weight	51 kDa
Amino Acids	456 aa
UniProt ID	P47869
NCBI Gene ID	2566
Ensembl ID	ENSG00000151834
OMIM	137142
GeneCards	GABRA2
Human Protein Atlas	GABRA2
Associated Diseases	Diabetes, Als, Neurodegeneration, Inflammation, neurodegeneration
KG Connections	4 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: gabra2 — AlphaFold P47869 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GABRA2 Gene

gene · 2685 words

→

Pathway Diagram

graph TD
    GABRA2["GABRA2"]
    GABRA2 -->|"target for"| Diabetes["Diabetes"]
    GABRA2 -->|"target for"| Ms["Ms"]
    GABRA2 -->|"target for"| Inflammation["Inflammation"]
    GABRA2 -->|"target for"| Neurodegeneration["Neurodegeneration"]
    GABRA2 -->|"target for"| DIABETES_MELLITUS["DIABETES MELLITUS"]
    GABRA2 -->|"regulates"| IL_6["IL-6"]
    GABRA2 -->|"target for"| STAT3["STAT3"]
    GABRA2 -->|"target for"| APOPTOSIS["APOPTOSIS"]
    JAK["JAK"] -->|"regulates"| GABRA2
    JAK2["JAK2"] -->|"target for"| GABRA2
    PI3K["PI3K"] -->|"target for"| GABRA2
    PTGS2["PTGS2"] -->|"regulates"| GABRA2
    CYTOKINES["CYTOKINES"] -->|"target for"| GABRA2
    AKT["AKT"] -->|"target for"| GABRA2
    PROINFLAMMATORY_CYTOKINES["PROINFLAMMATORY CYTOKINES"] -->|"target for"| GABRA2
    INFLAMMATION["INFLAMMATION"] -->|"target for"| GABRA2

Outgoing (41)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:GABRA2	data_in	dataset_row	0.00
Neurodegeneration	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
DIABETES MELLITUS	therapeutic_target	gene	0.60
IL-6	regulates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
INSULIN RESISTANCE	therapeutic_target	gene	0.60
Akt	therapeutic_target	pathway	0.60
Er Stress	therapeutic_target	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
Jak-Stat	regulates	pathway	0.60
MAOA	targets	gene	0.60
Pi3K	therapeutic_target	pathway	0.60
SLC6A4	targets	gene	0.60
IL6	targets	gene	0.60
FOXP1	associated_with	gene	0.60
AKT1	therapeutic_target	gene	0.60
TNF	targets	gene	0.60
Neuron	therapeutic_target	cell_type	0.60
Apoptosis	associated_with	pathway	0.60
SLC6A4	associated_with	gene	0.60
TNF	associated_with	gene	0.60
Epigenetic	associated_with	pathway	0.60
Dna Methylation	associated_with	pathway	0.60
IL6	associated_with	gene	0.60
Mitochondrial Function	associated_with	pathway	0.60
MAOA	associated_with	gene	0.60
STAT3	therapeutic_target	gene	0.60
NR4A2	regulates	gene	0.60
CHOP	therapeutic_target	gene	0.60
Neuron	expressed_in	cell_type	0.55
AKT1	associated_with	gene	0.50
SLC6A4	associated_with	protein	0.50
MAOA	associated_with	protein	0.50
Proteins	associated_with	protein	0.50

Incoming (27)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:GABRA2	data_in	dataset_row	0.00
TNF	therapeutic_target	gene	0.60
IL6	therapeutic_target	gene	0.60
SLC6A4	therapeutic_target	gene	0.60
AKT1	targets	gene	0.60
JAK2	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
PTGS2	regulates	gene	0.60
AKT	therapeutic_target	gene	0.60
RHOT1	associated_with	gene	0.60
MIRO1	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
GENES	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
AND	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
IL6	associated_with	gene	0.60
TNF	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
AKT1	associated_with	gene	0.60
MAOA	associated_with	gene	0.60
MAOA	therapeutic_target	gene	0.60
JAK	regulates	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
PROINFLAMMATORY CYTOKINES	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning gabra2 in their description or question text

No additional research found