| Gene Symbol | LPL |
| Full Name | Lipoprotein Lipase |
| Aliases | LPLPROTEIN |
| Protein Type | Enzyme |
| Function | Lipoprotein Lipase (LPL) is a key enzyme in lipid metabolism that hydrolyzes triglycerides in circulating lipoproteins, primarily chylomicrons and very-low-density lipoproteins (VLDL). |
| Primary Expression | neurons (especially in hippocampus and cortex), astrocytes, and microglia - Regional Distribution: High expression i |
| Pathways | Cholesterol, Glycolysis, Immune Response, Lipid Metabolism, Oxidative Phosphorylation |
| GeneCards | LPL |
| Human Protein Atlas | LPL |
| Lid region | Flexible loop covering the active site, undergoes conformational change upon substrate binding |
| Heparin-binding domain | Positively charged region for attachment to endothelial heparan sulfate |
| Neuronal energy source | Provides fatty acids for oxidative metabolism |
| Myelin synthesis | Delivers lipids for myelin sheath maintenance |
| Synaptic function | Supports membrane lipid composition |
| Glial function | Regulates astrocyte and microglial lipid homeostasis [2] |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer's disease, Dementia, Diabetes |
| Interactions | ADRA2A, ALDH1A2, ALZHEIMER'S DISEASE, AMPK, AND, APOE |
| KG Connections | 246 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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