gene 1,116 words KG: LITAF
Contents

LITAF — Lipopolysaccharide-Induced Tumor Necrosis Factor Factor

🧬 Gene Info
Gene SymbolLITAF
Full NameLipopolysaccharide-Induced Tumor Necrosis Factor Factor
AliasesSIMPLE, CMT1C
Chromosome16p13.13
FunctionThe protein contains several functional domains
Subcellular Localizationthe lysosomal membrane and late endosome compartments. The protein contains several functional domains:
Molecular Weight17 kDa
Amino Acids161 aa
PathwaysAutophagy, Cell Cycle, Immune Response, Mtor
UniProt IDQ9Y5K2
NCBI Gene ID10868
Ensembl IDENSG00000106789
OMIM604577
GeneCardsLITAF
Human Protein AtlasLITAF
Associated DiseasesALS, Alzheimer's disease, frontotemporal dementia
InteractionsGENES, IL18, IRF1, JUN, Nfkb, NFKBIA
KG Connections74 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (3)

Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Extracellular Vesicle Biogenesis Modulation
Score: 0.58

Related Analyses (2)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (13)

Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: regulates
Genes
index · KG edge: activates
ADCY9 Gene
gene · KG edge: regulates
ADRA1D Gene
gene · KG edge: regulates
CALM2 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

VEGF activates LITAF
IL18 activates LITAF
TNF activates LITAF
P38 activates LITAF
PPP5C regulates LITAF
JUN activates LITAF
ADRA1D regulates LITAF
PDK4 regulates LITAF
LITAF regulates IL6R
LITAF regulates MERTK

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