gene

UROCORTIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UROCORTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections

0Hypotheses

0Analyses

23Outgoing

7Incoming

0Experiments

0Debates

Summary

UROCORTIN encodes a neuroprotective peptide in the corticotropin-releasing hormone family, implicated in Parkinson's disease, Alzheimer's disease, and stress response pathways

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🧬 Gene Info

Gene Symbol	UROCORTIN
Chromosome	2p23.3
Function	encodes a 40-amino acid neuropeptide belonging to the corticotropin-releasing hormone (CRH) family.
Primary Expression	pituitary, cortex, and cerebellum
Molecular Weight	4.7 kDa
Amino Acids	40 aa
Pathways	Blood-Brain Barrier, Neuroprotection
UniProt ID	[Q9UBP3](https://www.uniprot.org/uniprot/Q9UBP3)
Ensembl ID	ENSG00000163794
GeneCards	UROCORTIN
Human Protein Atlas	UROCORTIN
Hypothalamus	Highest expression in the paraventricular nucleus (PVN), where it co-localizes with CRH neurons
Amygdala	Abundant in the central nucleus, involved in emotional processing
Hippocampus	Expression in CA1-CA3 regions and dentate gyrus[@bayatti2003]
Cortex	Moderate expression throughout cortical layers
Associated Diseases	Parkinson's disease, Alzheimer's disease
Interactions	AND, CRH, CRHR1, Leptin
KG Connections	30 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

UROCORTIN Gene

gene · 1128 words

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Pathway Diagram

graph TD
    UROCORTIN["UROCORTIN"]
    Ms{"Ms"}
    UROCORTIN -->|"regulates"| Ms
    CRH["CRH"]
    UROCORTIN -->|"associated with"| CRH
    CRHR1["CRHR1"]
    UROCORTIN -->|"associated with"| CRHR1
    AND["AND"]
    UROCORTIN -->|"associated with"| AND
    neurodegeneration["neurodegeneration"]
    UROCORTIN -->|"implicated in"| neurodegeneration
    CRH -->|"associated with"| UROCORTIN
    CRHR1 -->|"associated with"| UROCORTIN
    style UROCORTIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (23)

Target	Relation	Type	Str
Ms	regulates	disease	0.65
Als	regulates	disease	0.65
Anxiety	regulates	disease	0.65
ALS	regulates	disease	0.65
AND	activates	gene	0.60
App	regulates	protein	0.60
CRH	associated_with	gene	0.60
CRHR1	associated_with	gene	0.60
Leptin	interacts_with	protein	0.60
CRH	interacts_with	gene	0.60
Blood-Brain Barrier	activates	pathway	0.60
Endothelial	activates	cell_type	0.60
Neuron	associated_with	cell_type	0.60
Neuron	transports	cell_type	0.60
AND	associated_with	gene	0.60
Endothelial Cell	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
CRHR1	interacts_with	gene	0.50
NEURONS	expressed_in	concept	0.50
ENDOTHELIAL	activates	concept	0.50
ENDOTHELIAL CELLS	activates	concept	0.50
ANXIETY	regulates	gene	0.50
Neuroprotection	regulates	process	0.50

Incoming (7)

Source	Relation	Type	Str
AND	interacts_with	gene	0.60
CRH	interacts_with	entity	0.60
CRHR1	interacts_with	entity	0.60
AND	associated_with	gene	0.60
ANXIETY	regulates	gene	0.60
CRH	associated_with	gene	0.60
CRHR1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning UROCORTIN in their description or question text

No additional research found