gene

TNFRSF1B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNFRSF1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections

0Hypotheses

1Analyses

41Outgoing

19Incoming

0Experiments

1Debates

Summary

Page for TNFRSF1B Gene

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🧬 Gene Info

Gene Symbol	TNFRSF1B
Aliases	TNFR2
Protein Type	Receptor
Function	encodes a type I membrane receptor for tumor necrosis factor (TNF).
Molecular Weight	75 kDa
Amino Acids	461 aa
Exons	10
Pathways	NF-κB, NF-κB pathway, PI3K, MAPK pathway, MAPK Pathway
Ensembl ID	ENSG00000028137
GeneCards	TNFRSF1B
Human Protein Atlas	TNFRSF1B
[NF-κB](/entities/nf-kb) activation	TNFR2 activates the non-canonical NF-κB pathway via TRAF2/TRAF3, promoting cell survival genes
PI3K/Akt pathway	Signals through PI3K to activate Akt, promoting neuronal survival
JNK modulation	Unlike TNFR1, TNFR2 does not directly activate pro-apoptotic JNK signaling
No death domain	TNFR2 lacks an intracellular death domain, precluding direct apoptotic signaling
Associated Diseases	Cancer, Chronic Pain, Leukemia, Lung Cancer, Pain
Interactions	ADRA2B, AND, ASTROCYTE, CHRM4, CHRNE, CRH
KG Connections	60 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TNFRSF1B["TNFRSF1B"]
    Cancer["Cancer"]
    Leukemia["Leukemia"]
    Lung_Cancer["Lung Cancer"]
    Als["Als"]
    CANCER["CANCER"]
    ADAM8["ADAM8"]
    AND["AND"]
    TNF["TNF"]
    GABA["GABA"]
    TNFRSF13C["TNFRSF13C"]
    HCRTR1["HCRTR1"]
    CYTOKINES["CYTOKINES"]
    Wnt["Wnt"]
    Microglia["Microglia"]
    Astrocyte["Astrocyte"]
    CHRM4["CHRM4"]
    MYO7A["MYO7A"]
    GRM2["GRM2"]
    WNT1["WNT1"]
    ASTROCYTE["ASTROCYTE"]
    TNFRSF1B -.-|"associated"| Cancer
    TNFRSF1B -.-|"associated"| Leukemia
    TNFRSF1B -.-|"associated"| Lung_Cancer
    TNFRSF1B -->|"activates"| Als
    TNFRSF1B -.-|"associated"| CANCER
    TNFRSF1B -.-|"associated"| ADAM8
    TNFRSF1B -.-|"associated"| AND
    TNFRSF1B -.-|"associated"| TNF
    TNFRSF1B -->|"activates"| GABA
    TNFRSF1B -->|"activates"| TNFRSF13C
    TNFRSF1B -->|"activates"| HCRTR1
    TNFRSF1B -->|"activates"| CYTOKINES
    TNFRSF1B -->|"activates"| Wnt
    TNFRSF1B -->|"activates"| Microglia
    TNFRSF1B -->|"activates"| Astrocyte
    CHRM4 -->|"activates"| TNFRSF1B
    MYO7A -->|"activates"| TNFRSF1B
    GRM2 -->|"activates"| TNFRSF1B
    WNT1 -->|"activates"| TNFRSF1B
    ASTROCYTE -->|"activates"| TNFRSF1B
    style TNFRSF1B fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (41)

Target	Relation	Type	Str
synaptic_plasticity	regulates	phenotype	0.70
Als	activates	disease	0.65
ALS	activates	disease	0.65
Chronic Pain	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Leukemia	associated_with	disease	0.65
Lung Cancer	associated_with	disease	0.65
CANCER	associated_with	gene	0.60
GRM2	activates	gene	0.60
TNFRSF13C	activates	gene	0.60
HCRTR1	activates	gene	0.60
WNT1	activates	gene	0.60
Rb	activates	protein	0.60
Cytokine	activates	protein	0.60
AND	associated_with	gene	0.60
Astrocyte	activates	cell_type	0.60
WNT	activates	gene	0.60
AND	activates	gene	0.60
GENES	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
Leptin	associated_with	protein	0.60
CYTOKINES	activates	gene	0.60
Wnt	activates	pathway	0.60
Microglia	activates	cell_type	0.60
CHRNE	activates	gene	0.60
GABA	activates	gene	0.60
ADAM8	associated_with	gene	0.60
TNF	associated_with	gene	0.60
GRIN3B	activates	gene	0.60
CRH	activates	gene	0.60
WNT11	activates	gene	0.60
MYO7A	activates	gene	0.60
CHRM4	activates	gene	0.60
ADRA2B	activates	gene	0.60
IL13	activates	gene	0.60
Microglia	expressed_in	cell_type	0.55
Astrocyte	expressed_in	cell_type	0.55
Brainstem	expressed_in	brain_region	0.55
CYTOKINE	activates	concept	0.50
Pain	associated_with	disease	0.50
Proteins	associated_with	protein	0.50

Incoming (19)

Source	Relation	Type	Str
TNF	interacts_with	protein	0.80
TNF	biomarker_for	gene	0.60
ASTROCYTE	activates	gene	0.60
WNT	activates	gene	0.60
TNF	associated_with	gene	0.60
GABA	activates	gene	0.60
CYTOKINES	activates	gene	0.60
CHRM4	activates	gene	0.60
MYO7A	activates	gene	0.60
GRM2	activates	gene	0.60
WNT1	activates	gene	0.60
CRH	activates	gene	0.60
ADRA2B	activates	gene	0.60
IL13	activates	gene	0.60
CHRNE	activates	gene	0.60
WNT11	activates	gene	0.60
GRIN3B	activates	gene	0.60
TNFRSF13C	activates	gene	0.60
HCRTR1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Why do systemic anti-inflammatory drugs fail in AD despite cardiovascular effica

clinical neurology | 2026-04-08 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate noted clinical failures of TNF-α and IL-6 inhibitors in AD despite th

closed · Rounds: 4 · Score: 0.79 · 2026-04-09

Related Research

Hypotheses and analyses mentioning TNFRSF1B in their description or question text

No additional research found