concept

FTLD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FTLD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

555Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

1Experiments

2Debates

Summary

FTLD is a concept in neurodegeneration research. Key relationships include: associated with, biomarker for, interacts with. Associated with Aging, Als, Alzheimer. Connected to 123 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	FTLD
Key Genes/Proteins	AGING, ALDH1L1, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID
Related Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Alzheimer'S Disease
Related Pathways	Adaptive Immunity, Amyloid
Linked Hypotheses	1 hypotheses

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FTLD["FTLD"]
    FTLD -->|"interacts"| Inflammation["Inflammation"]
    FTLD -->|"interacts"| Ms["Ms"]
    FTLD -->|"expressed in"| Alzheimer["Alzheimer"]
    FTLD -->|"phosphorylates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    FTLD -->|"causes"| Aging["Aging"]
    FTLD -->|"interacts"| INFLAMMATION["INFLAMMATION"]
    FTLD -->|"interacts"| ULK1["ULK1"]
    FTLD -.protects against.-> C9ORF72["C9ORF72"]
    FTLD -.protects against.-> HEXANUCLEOTIDE_REPEAT_EXPANSIO["HEXANUCLEOTIDE REPEAT EXPANSIONS"]
    FTLD -.protects against.-> GRN["GRN"]
    FIP200["FIP200"] -->|"interacts"| FTLD
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"expressed in"| FTLD
    APOE4["APOE4"] -->|"expressed in"| FTLD
    DNA["DNA"] -->|"expressed in"| FTLD
    FUS["FUS"] -->|"causes"| FTLD
    ALZHEIMER["ALZHEIMER"] -->|"expressed in"| FTLD
    AND["AND"] -->|"phosphorylates"| FTLD
    TARDBP["TARDBP"] -->|"expressed in"| FTLD
    ALS["ALS"] -->|"phosphorylates"| FTLD

Outgoing (421)

Target	Relation	Type	Str
Early-Onset Dementia	causes	disease	0.95
Cognitive Function Deterioration	causes	phenotype	0.95
Als	associated_with	disease	0.95
neurons	expressed_in	cell_type	0.90
oxidative stress response	participates_in	pathway	0.90
Ftd	associated_with	disease	0.90
Social-Emotional-Behavioural Changes	causes	phenotype	0.90
Language Changes	causes	phenotype	0.90
frontotemporal dementia	interacts_with	disease	0.90
Motor Disorder	causes	phenotype	0.85
Amyotrophic Lateral Sclerosis	associated_with	disease	0.85
neurodegeneration	associated_with	disease	0.80
neurodegeneration	interacts_with	disease	0.80
ALS	interacts_with	disease	0.80
frontotemporal dementia	causes	disease	0.80
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.80
ALS	associated_with	gene	0.80
Neurodegeneration	biomarker_for	disease	0.75
GRN	regulates	gene	0.70
Alzheimer's disease	interacts_with	disease	0.70
cortex	expressed_in	brain_region	0.70
TDP43	interacts_with	gene	0.70
frontotemporal dementia	associated_with	disease	0.70
frontotemporal dementia	regulates	disease	0.70
RNA	regulates	gene	0.70
frontotemporal dementia	biomarker_for	disease	0.70
neurodegeneration	regulates	disease	0.70
NEURODEGENERATIVE DISEASES	associated_with	gene	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
NEURODEGENERATION	biomarker_for	gene	0.70
Aging	activates	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Frontotemporal Dementia	regulates	disease	0.65
Epilepsy	associated_with	disease	0.65
Als	degrades	disease	0.65
Depression	associated_with	disease	0.65
Als	encodes	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Spinocerebellar Ataxia	causes	disease	0.65
ALS	activates	disease	0.65
Schizophrenia	associated_with	disease	0.65
Neurodegeneration	degrades	disease	0.65
Parkinson	associated_with	disease	0.65
Ataxia	causes	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Aging	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Spinocerebellar Ataxia	expressed_in	disease	0.65
Huntington	expressed_in	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65

Incoming (134)

Source	Relation	Type	Str
TDP-43	associated_with	protein	0.95
TDP-43	associated_with	protein	0.95
C9ORF72	risk_factor_for	gene	0.90
ALS	associated_with	gene	0.90
GRN	implicated_in	gene	0.80
UBQLN2	implicated_in	gene	0.80
MAPT	implicated_in	gene	0.80
ALS	interacts_with	gene	0.80
TARDBP	associated_with	gene	0.80
SQSTM1	associated_with	gene	0.80
OPTN	associated_with	gene	0.80
C9ORF72	associated_with	gene	0.80
DNA	interacts_with	gene	0.80
ALS	regulates	gene	0.70
DEPRESSION	associated_with	gene	0.60
HUNTINGTON	associated_with	gene	0.60
LONP1	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
ROS	regulates	gene	0.60
TBK1	associated_with	gene	0.60
ANXA11	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
ALS	causes	gene	0.60
levodopa	targets	drug	0.60
ANO9	implicated_in	gene	0.60
C3AR1	associated_with	gene	0.60
CHMP2B	causes	gene	0.60
ATXN2	causes	gene	0.60
HUNTINGTON	expressed_in	gene	0.60
PARK7	expressed_in	gene	0.60
PARKINSON	causes	gene	0.60
NFE2L2	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
ALDH1L1	expressed_in	gene	0.60
C9ORF72	expressed_in	gene	0.60
ATG	interacts_with	gene	0.60
SMCR8	associated_with	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
APOE4	expressed_in	gene	0.60
DNA	expressed_in	gene	0.60
FUS	causes	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
TARDBP	expressed_in	gene	0.60
ALS	phosphorylates	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
AND	associated_with	gene	0.60
NRF2	associated_with	gene	0.60
NEURON	activates	gene	0.60
AND	activates	gene	0.60
RNA	transports	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Aβ42 oligomers drive TDP-43 phosphorylation at s409/410 thro	0.595	neurodegeneration	What mechanisms drive TDP-43 pathology s

Mentioning Analyses (2)

Scientific analyses that reference this entity

What molecular mechanisms enable functional recovery and muscle re-innervation a

neurodegeneration | 2026-04-14 | 2 hypotheses Top: 0.683

What mechanisms drive TDP-43 pathology specifically in Alzheimer's disease versu

neurodegeneration | 2026-04-07 | 3 hypotheses Top: 0.595

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
FTLD-Tau vs FTLD-TDP In Vivo Biomarker Differentiation	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$6,550,000

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

TDP-43 inclusions occur in AD, ALS, and FTLD but the pathogenic mechanisms leadi

closed · Rounds: 4 · Score: 0.70 · 2026-04-21

The study shows dramatic functional recovery and muscle re-innervation after cyt

closed · Rounds: 4 · Score: 0.85 · 2026-04-15

Related Research

Hypotheses and analyses mentioning FTLD in their description or question text

No additional research found