gene 663 words KG: GOLGA8FTLDFET
Contents

GOLGA8: A New FTLD-FET Gene with Dinucleotide Repeat Expansion

🧬 Gene Info
Gene SymbolGOLGA8FTLDFET
Functionis a spectrum of neurodegenerative diseases characterized by abnormal protein aggregates containing FET family proteins (FUS), TAF15, and EWS.
Primary Expressionneuronal tissues and is localized to the Golgi apparatus, where it plays a role in protein sorting and trafficking
Subcellular Localizationthe Golgi apparatus, where it plays a role in protein sorting and trafficking
GeneCardsGOLGA8FTLDFET
Human Protein AtlasGOLGA8FTLDFET
GeneGOLGA8 (GOLGA8A/GOLGA8B)
VariantCT dinucleotide repeat expansion in intron
Statistical Strengthp = 5.8 × 10⁻²¹, making this one of the strongest genetic associations for a sporadic neurodegenerative disease[@rosa2026]
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (8)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
CYP46A1 Overexpression Gene Therapy
Score: 0.92
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
FTLD-Tau vs FTLD-TDP In Vivo Biomarker Differentiation
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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