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disease 988 words KG: ent-dise-11e44ef4
Contents

FTLD-ALS: Frontotemporal Lobar Degeneration with Motor Neuron Disease

Disease Info
Motor [Cortex](/brain-regions/cortex)TDP-43 inclusions, neuronal loss
Spinal CordAnterior horn cell loss, gliosis
Frontal/Temporal CortexTDP-43 inclusions, microvacuolation
[Hippocampus](/brain-regions/hippocampus)TDP-43 in dentate gyrus and CA1
DatabasesOMIMOrphanetClinicalTrialsPubMed

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Related Hypotheses (7)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38Cross-Seeding Prevention Strategy
Score: 0.69Glycine-Rich Domain Competitive Inhibition
Score: 0.64Cryptic Exon Silencing Restoration
Score: 0.53Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77Smartphone-Detected Motor Variability Correction
Score: 0.74RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (24)

RNA binding protein dysregulation across ALS FTD AD
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · completedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (25)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40TMEM106B Haplotype as Genetic Modifier in FTD — Mechanism an
validation · proposed · Score: 0.40FTLD-Tau vs FTLD-TDP In Vivo Biomarker Differentiation
clinical · proposed · Score: 0.40Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk
clinical · proposed · Score: 0.40

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