gene

DNAJC5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNAJC5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

55Connections

0Hypotheses

0Analyses

38Outgoing

17Incoming

0Experiments

0Debates

Summary

Page for DNAJC5 Gene

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🧬 Gene Info

Gene Symbol	DNAJC5
Chromosome	10q24.32
Protein Family	DnaJ/Hsp40 co-chaperone family
Protein Type	Chaperone
Function	is a synaptic molecular chaperone essential for neuronal function and survival.
Subcellular Localization	Synaptic vesicles, plasma membrane, cytoplasm
Molecular Weight	22.4 kDa
Amino Acids	198 aa
Exons	6
UniProt ID	Q9H3X5
NCBI Gene ID	80331
Ensembl ID	ENSG00000170584
GeneCards	DNAJC5
Human Protein Atlas	DNAJC5
Associated Diseases	adult-onset neuronal ceroid lipofuscinosis, Als, disease, Huntington, neurodegeneration
Interactions	Actin, App, CALB2, GENES, NEURODEGENERATION, Rb
KG Connections	55 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DNAJC5 — AlphaFold Q9H3X5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DNAJC5["DNAJC5"]
    Ms{"Ms"}
    DNAJC5 -->|"regulates"| Ms
    Als{"Als"}
    DNAJC5 -->|"associated_with"| Als
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    DNAJC5 -->|"regulates"| Amyotrophic_Lateral_Sclerosis
    ATG7(["ATG7"])
    DNAJC5 -->|"regulates"| ATG7
    VAMP7(["VAMP7"])
    DNAJC5 -->|"regulates"| VAMP7
    AND(["AND"])
    DNAJC5 -->|"regulates"| AND
    AMYOTROPHIC_LATERAL_SCLEROSIS(["AMYOTROPHIC LATERAL SCLEROSIS"])
    AMYOTROPHIC_LATERAL_SCLEROSIS -->|"regulates"| DNAJC5
    RAB8A(["RAB8A"])
    RAB8A -->|"regulates"| DNAJC5
    ALS(["ALS"])
    ALS -->|"associated_with"| DNAJC5
    RAB11A(["RAB11A"])
    RAB11A -->|"regulates"| DNAJC5
    style DNAJC5 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (38)

Target	Relation	Type	Str
Als	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Huntington	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Ataxia	regulates	disease	0.65
ALS	interacts_with	disease	0.65
Spinocerebellar Ataxia	regulates	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	regulates	disease	0.65
Neuron	causes	cell_type	0.60
AND	regulates	gene	0.60
Actin	interacts_with	protein	0.60
ALS	associated_with	disease	0.60
Huntington	associated_with	disease	0.60
adult-onset neuronal ceroid lipofuscinosis	causes	disease	0.60
Synaptic Vesicle	interacts_with	pathway	0.60
neurodegeneration	activates	disease	0.60
neurodegeneration	causes	disease	0.60
Rb	interacts_with	protein	0.60
neurodegeneration	associated_with	disease	0.60
RAB27A	regulates	gene	0.60
neurons	expressed_in	cell_type	0.60
ATG7	regulates	gene	0.60
VAMP7	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
Fus	causes	protein	0.60
App	interacts_with	protein	0.60
Neuron	expressed_in	cell_type	0.55
CALB2	activates	gene	0.50
ROCK2	activates	gene	0.50
STXBP1	co_expressed_with	gene	0.50
DNAJC6	co_expressed_with	gene	0.50
ROCK2	co_expressed_with	gene	0.50
HSP40	associated_with	protein	0.50
disease	causes	disease	0.50
NEURODEGENERATIVE DISEASE	causes	concept	0.50
disease	interacts_with	disease	0.50

Incoming (17)

Source	Relation	Type	Str
SYNAPSE	regulates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
HUNTINGTON'S DISEASE	regulates	gene	0.60
HUNTINGTON	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
NEURODEGENERATION	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
RAB8A	regulates	gene	0.60
RAB11A	regulates	gene	0.60
STXBP1	interacts_with	gene	0.60
DNAJC6	regulates	gene	0.60
ROCK2	activates	gene	0.60
CALB2	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.60
ALS	associated_with	gene	0.60
Neurodegeneration	activates	disease	0.50
CALB2	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DNAJC5 in their description or question text

No additional research found