gene 625 words KG: DLK
Contents

DLK — Dual Leucine Zipper Kinase

🧬 Gene Info
Gene SymbolDLK
Full NameDual Leucine Zipper Kinase
AliasesMAP3K12
Protein TypeKinase
FunctionDLK functions as a master regulator of the stress-activated protein kinase (SAPK) signaling cascade:
Molecular Weight105 kDa
Pathwayscascade: ### Axonal Injury Response
Ensembl IDENSG00000116809
GeneCardsDLK
Human Protein AtlasDLK
Associated DiseasesAging
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APOE, APOE3
KG Connections106 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (8)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (11)

blarcamesine-axon
clinical_trial · KG edge: causes
Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: inhibits
BAX Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

BAX activates DLK
PUMA activates DLK
DLK activates PUMA
ULK1 inhibits DLK
TAU inhibits DLK
ERK1 activates DLK
CFOS activates DLK
DLK activates APP
DLK activates RANK
DLK activates APOE4

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