gene 977 words KG: DLK1
Contents

DLK1 Gene

🧬 Gene Info
Gene SymbolDLK1
Full NameDelta Like Non-Canonical Notch Ligand 1
AliasesDelta-Like 1 Homolog
Chromosome14q32.12
Functionis a member of the epidermal growth factor (EGF)-like family that functions as a non-canonical Notch ligand and regulator of cell fate decisions.
Amino Acids396 aa
Exons8
PathwaysNotch
UniProt ID[O00548](https://www.uniprot.org/uniprot/O00548)
Ensembl IDENSG00000176358
OMIM176290
GeneCardsDLK1
Human Protein AtlasDLK1
N-terminal signal peptideDirects secretion
Multiple EGF-like repeatsSix EGF-like domains in the extracellular region
Associated DiseasesAls, ICPP, Idiopathic Central Precocious Puberty, Ms
InteractionsACC, ATG12, ATG16L1, ATG5, FERROPTOSIS, GABRA1
KG Connections62 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (4)

AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66

Related Analyses (4)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

acc-chronic-pain
cell_type · KG edge: activates
DNA Methylation
entity · KG edge: associated_with
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: associated_with
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: associated_with
Ferroptosis Validation in Parkinson's Disease
experiment · KG edge: activates

Knowledge Graph (12 edges)

GABRA1 associated_with DLK1
GAIN associated_with DLK1
DLK1 associated_with GABRA1
DLK1 interacts_with GABRA1
ATG12 inhibits DLK1
TFE3 interacts_with DLK1
DLK1 inhibits ATG16L1
DLK1 inhibits ATG5
DLK1 activates LC3
DLK1 associated_with GAIN

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