| Gene Symbol | MAP3K12 |
| Full Name | Mitogen-Activated Protein Kinase Kinase Kinase 12 |
| Aliases | MAP3K12PROTEIN |
| Protein Type | Kinase |
| Function | MAP3K12 (Mitogen-Activated Protein Kinase Kinase Kinase 12), also known as DLK (Dual-Leucine Zipper Kinase), is a serine/threonine protein kinase that functions as a key regulator of stress-activated |
| Primary Expression | neurons throughout the CNS - Regional Distribution: High expression in hippocampus, cortex |
| Pathways | MAPK pathway |
| GeneCards | MAP3K12 |
| Human Protein Atlas | MAP3K12 |
| Molecular weight | ~105 kDa |
| Kinase domain | Serine/threonine-specific protein kinase |
| Cellular localization | Primarily cytoplasmic, with nuclear translocation upon activation |
| Domain structure | N-terminal leucine zippers for dimerization, kinase domain, C-terminal regulatory regions |
| Transcriptional activation | Phosphorylation of c-Jun and other transcription factors |
| Apoptotic signaling | Activation of pro-apoptotic genes |
| Associated Diseases | neurodegeneration |
| Interactions | DRP1 |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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