gene 649 words KG: CTSH
Contents

CTSH Gene

🧬 Gene Info
Gene SymbolCTSH
Chromosome15q25.1 [@hook2018]
Protein TypeProtease
Functionis a gene involved in cellular processes relevant to neurodegeneration.
Primary Expressionvarious tissues:
Molecular Weight37 kDa
Amino Acids253 aa
Pathwayssignaling:** Regulation of growth factors
UniProt IDP09668
NCBI Gene ID1515
Ensembl IDENSG00000103852
GeneCardsCTSH
Human Protein AtlasCTSH
Associated DiseasesAlzheimer, Dementia, Ms
InteractionsActin, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, AMYOTROPHIC LATERAL SCLEROSIS
KG Connections151 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (13)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76

Related Analyses (4)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (10)

Astrocytes
cell · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
ABI3 Gene
gene · KG edge: associated_with
ACE Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CTSH interacts_with C1QB
CTSH activates SOD1
CTSH interacts_with HSP27
CR2 associated_with CTSH
TREM2 associated_with CTSH
IL6 associated_with CTSH
ZCWPW1 associated_with CTSH
CTSH associated_with PILRB
CTSH associated_with GBA
CTSH associated_with CR1

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