gene 1,391 words KG: CPT2
Contents

CPT2

🧬 Gene Info
Gene SymbolCPT2
AliasesCarnitine Palmitoyltransferase 2
Chromosome1p32.3
Protein TypeEnzyme
Functionencodes a mitochondrial enzyme that catalyzes the conversion of acylcarnitine esters back to free carnitine and fatty acyl-CoA esters.
Amino Acids659 aa
PathwaysAmyloid, Lipid Metabolism, Mitochondrial Function, Oxidative Phosphorylation
Ensembl IDENSG00000157184
GeneCardsCPT2
Human Protein AtlasCPT2
Transmembrane anchorA single transmembrane helix that localizes the protein to the inner mitochondrial membrane
Catalytic domainThe bulk of the protein faces the mitochondrial matrix where catalysis occurs
Substrate binding pocketContains residues for carnitine and acyl-CoA binding
Associated DiseasesAls, Cancer, Cardiac, Heart Failure, Tumor
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-Β PLAQUES, AND, CANCER
KG Connections73 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (17)

Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.85
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78

Related Analyses (2)

Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

AECII-specific HMGCS2 overexpression in mouse pulmonary fibr
validation · proposed · Score: 0.95
HMGCS2 gain-of-function in AECII lipid metabolism regulation
exploratory · proposed · Score: 0.90

See Also (10)

Cardiac MIBG Scan for Parkinsonism
diagnostic · KG edge: implicated_in
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
Genes
index · KG edge: associated_with
ADRB1 Gene
gene · KG edge: associated_with
ATG7 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

UBIQUITIN activates CPT2
CPT2 inhibits SLC44A2
CPT2 activates MUL1
PINK1 implicated_in CPT2
PARL implicated_in CPT2
CPT2 implicated_in USP30
CPT2 implicated_in PARKIN
MAPK1 associated_with CPT2
HDAC3 associated_with CPT2
CRYAB associated_with CPT2

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