gene 2,688 words KG: CLU
Contents

CLU — Clusterin (Apolipoprotein J)

🧬 Gene Info
Gene SymbolCLU
Full NameClusterin (Apolipoprotein J)
AliasesPage for CLU Gene
Chromosome8p21.1
Functionis a gene located on chromosome 8p21.
Primary ExpressionHippocampus, Cortex, Basal ganglia, Cerebellum
Exons9
PathwaysAstrocyte Reactivity, Blood-Brain Barrier, Camp Signaling, Complement, Dysbiosis
UniProt IDP10909
NCBI Gene ID1115
Ensembl IDENSG00000120885
OMIM185551
GeneCardsCLU
Human Protein AtlasCLU
Associated Diseasesaging, Als, Alzheimer, Alzheimer disease
InteractionsABCA7, ACE2, Actin, AD, AKT, ALZHEIMER
SciDEX HypothesesHippocampus ages transcriptionally faster than cer
KG Connections1050 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (30)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55

Related Analyses (8)

What are the cell-type-specific transcriptomic signatures of
neurodegeneration · completed
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived
Extracellular vesicle biomarkers for early AD detection
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (15)

ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
ABI3 Gene
gene · KG edge: associated_with
adam17
gene · KG edge: associated_with
ACTN2 — Actinin Alpha 2
gene · KG edge: regulates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with

Knowledge Graph (12 edges)

CLU interacts_with PPARGC1A
CLU interacts_with BAX
CLU activates PPARGC1A
CLU regulates CLUSTERIN
CLU activates PPARG
CLU regulates C1S
CLU activates C1Q
CLU regulates CR1
CLU associated_with CFH
CLU activates TREM2

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