Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about appbp2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | APPBP2 |
| Full Name | Amyloid Precursor Protein Binding Protein 2 |
| Chromosome | 16q24.1 |
| Function | is a gene located on chromosome 16q24.1 that encodes a protein that binds to the cytoplasmic domain of Amyloid Precursor Protein (APP) |
| Primary Expression | Cerebral cortex, Hippocampus, Cerebellum, Testis |
| Subcellular Localization | , trafficking, and processing through proteasomal and autophagy-mediated pathways. APPBP2 is expressed in neurons and gl |
| Molecular Weight | 59 kDa |
| UniProt ID | Q92688 |
| NCBI Gene ID | 10513 |
| Ensembl ID | ENSG00000142541 |
| OMIM | 604390 |
| GeneCards | APPBP2 |
| Human Protein Atlas | APPBP2 |
| APP (Amyloid Precursor Protein) | Primary substrate and interaction partner |
| PSEN1 and PSEN2 | Presenilin components of γ-secretase complex affecting APP processing |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
APPBP2["APPBP2"] -->|"activates"| BACE1["BACE1"]
APPBP2["APPBP2"] -->|"activates"| BIN1["BIN1"]
APPBP2["APPBP2"] -->|"activates"| CLU["CLU"]
APPBP2["APPBP2"] -->|"activates"| PICALM["PICALM"]
APPBP2["APPBP2"] -->|"activates"| PSEN1["PSEN1"]
APPBP2["APPBP2"] -->|"implicated in"| neurodegeneration["neurodegeneration"]
APP["APP"] -->|"activates"| APPBP2["APPBP2"]
style APPBP2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style BACE1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style BIN1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style CLU fill:#4a1a6b,stroke:#333,color:#e0e0e0
style PICALM fill:#4a1a6b,stroke:#333,color:#e0e0e0
style PSEN1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style neurodegeneration fill:#006494,stroke:#333,color:#e0e0e0
style APP fill:#4a1a6b,stroke:#333,color:#e0e0e0| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:APPBP2 | data_in | dataset_row | 0.00 |
| APP | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning appbp2 in their description or question text
No additional research found