gene

CAMK2G

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CAMK2G: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections

0Hypotheses

0Analyses

3Outgoing

5Incoming

0Experiments

0Debates

Summary

CAMK2G — Calcium/Calmodulin-Dependent Kinase 2 Gamma

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🧬 Gene Info

Gene Symbol	CAMK2G
Full Name	Calcium/Calmodulin-Dependent Kinase 2 Gamma
Chromosome	10q22.2
Protein Type	Serine/Threonine Kinase
UniProt ID	Q13557
NCBI Gene ID	817
Ensembl ID	ENSG00000148660
GeneCards	CAMK2G
Human Protein Atlas	CAMK2G
Autophosphorylation	Creates calcium-independent activity, a molecular switch for memory [2]
Targets	AMPA receptors, NMDA receptors, transcription factors, cytoskeletal proteins
Brain	Hippocampus (CA1, CA3, dentate gyrus), cerebral cortex (layers II-VI), cerebellum, basal ganglia
Other tissues	Heart, skeletal muscle, testis, adrenal gland
Cellular localization	Postsynaptic densities, dendritic shafts, nuclear compartments
Dysregulated phosphorylation	Reduced CaMKII autophosphorylation in AD brains
Associated Diseases	neurodegeneration
KG Connections	8 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CAMK2G — AlphaFold Q13557 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CAMK2G — Calcium/Calmodulin-Dependent Kinase 2 Gamma

gene · 649 words

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Pathway Diagram

flowchart TD
    CAMK2G(["CAMK2G"])
    EGR1(["EGR1"])
    CEBPA(["CEBPA"])
    Rb(["Rb"])
    FOS(["FOS"])
    MYC(["MYC"])
    WT1(["WT1"])
    ERBB2(["ERBB2"])
    FOSB(["FOSB"])
    neurodegeneration["neurodegeneration"]

    CAMK2G -->|"associated with"| EGR1
    CAMK2G -->|"expressed in"| CEBPA
    CAMK2G -->|"expressed in"| Rb
    FOS -->|"expressed in"| CAMK2G
    MYC -->|"associated with"| CAMK2G
    WT1 -->|"expressed in"| CAMK2G
    ERBB2 -->|"expressed in"| CAMK2G
    FOSB -->|"expressed in"| CAMK2G
    CAMK2G -->|"implicated in"| neurodegeneration

    style CAMK2G fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (3)

Target	Relation	Type	Str
EGR1	associated_with	gene	0.60
CEBPA	expressed_in	gene	0.60
Rb	expressed_in	protein	0.60

Incoming (5)

Source	Relation	Type	Str
FOS	expressed_in	gene	0.60
MYC	associated_with	gene	0.60
FOSB	expressed_in	gene	0.60
WT1	expressed_in	gene	0.60
ERBB2	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CAMK2G in their description or question text

No additional research found