gene

CACNA2D3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CACNA2D3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

0Hypotheses

0Analyses

1Outgoing

12Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	CACNA2D3
Protein Type	Gene
Function	CACNA2D3 resides on chromosome 3p21.1 and produces a precursor polypeptide that is post-translationally cleaved into alpha2 and delta components, which remain linked by disulfide bonds.
GeneCards	CACNA2D3
Human Protein Atlas	CACNA2D3
Trafficking amplifier	boosts membrane delivery and stability of Cav channel complexes.[@dolphin2012][@eroglu2009]
Kinetic modulation	alters channel activation/inactivation profile and calcium current density.[@dolphin2012]
Synaptogenic signaling interface	alpha2delta proteins can engage extracellular matrix ligands that shape synapse formation and maturation.[@eroglu2009]
Associated Diseases	neurodegeneration
KG Connections	13 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CACNA2D3 Gene

gene · 871 words

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Pathway Diagram

graph TD
    CACNA2D3["CACNA2D3"]
    PRKAB1["PRKAB1"]
    CACNA2D3 -->|"therapeutic_target"| PRKAB1
    neurodegeneration["neurodegeneration"]
    CACNA2D3 -->|"implicated in"| neurodegeneration
    EPAS1["EPAS1"]
    EPAS1 -->|"associated with"| CACNA2D3
    CACNG6["CACNG6"]
    CACNG6 -->|"associated with"| CACNA2D3
    BIN1["BIN1"]
    BIN1 -->|"associated with"| CACNA2D3
    CHRNA2["CHRNA2"]
    CHRNA2 -->|"therapeutic_target"| CACNA2D3
    CEBPA["CEBPA"]
    CEBPA -->|"associated with"| CACNA2D3
    GENES["GENES"]
    GENES -->|"therapeutic_target"| CACNA2D3
    CNR1["CNR1"]
    CNR1 -->|"therapeutic_target"| CACNA2D3
    style CACNA2D3 fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7

Outgoing (1)

Target	Relation	Type	Str
PRKAB1	therapeutic_target	gene	0.60

Incoming (12)

Source	Relation	Type	Str
DIABETIC RETINOPATHY	therapeutic_target	gene	0.60
EPAS1	associated_with	gene	0.60
CACNG6	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
CHRNA2	therapeutic_target	gene	0.60
CEBPA	associated_with	gene	0.60
CNR1	therapeutic_target	gene	0.60
CTSD	associated_with	gene	0.60
NME1	therapeutic_target	gene	0.60
CACNA1E	associated_with	gene	0.60
PRKAB1	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CACNA2D3 in their description or question text

No additional research found