gene 870 words KG: C3AR1
Contents

C3AR1 Gene

🧬 Gene Info
Gene SymbolC3AR1
Full NameComplement C3a Receptor 1
Chromosome5p13.3
Protein TypeReceptor
FunctionC3AR1 encodes a seven-transmembrane G protein-coupled receptor that specifically binds the complement activation fragment C3a.
PathwaysBLOOD_CSF_BARRIER
UniProt IDQ16581
NCBI Gene ID719
Ensembl IDENSG00000171860
GeneCardsC3AR1
Human Protein AtlasC3AR1
Associated DiseasesAging, Als, Alzheimer, Cancer, Cardiovascular
Known Drugs/CompoundsSB290157
Interactionsadcy2, ADCY2, ALZHEIMER, ALZHEIMER'S DISEASE, APOPTOSIS, C1QA
KG Connections200 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (10)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
...
Score: 0.68
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
TREM2-mediated microglial tau clearance enhancement
Score: 0.62

Related Analyses (6)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (7)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.40

See Also (11)

Apoptosis in Neurodegeneration
entity · KG edge: activates
ADCY2 — Adenylate Cyclase 2
gene · KG edge: associated_with
AIF1 Gene
gene · KG edge: associated_with
ANO9 — Anoctamin 9
gene · KG edge: biomarker_for
C1QA Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

C3AR1 regulates M2_POLARIZATION
SB290157 inhibits C3AR1
C3 activates C3AR1
C3A activates C3AR1
C3AR1 regulates MOTOR_IMPAIRMENT
C3AR1 regulates BLOOD_CSF_BARRIER
C3AR1 regulates MICROGLIAL_RECRUITMENT
GBM expressed_in C3AR1
C3AR1 expressed_in GBM
C3AR1 biomarker_for RBPJL

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