Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about C3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Neuronal Development | inhibits | process | 0.90 |
| C3AR | activates | protein | 0.90 |
| Cognitive Impairment | correlates_with | phenotype | 0.90 |
| C3AR1 | activates | protein | 0.87 |
| Dendritic Arborization | inhibits | process | 0.85 |
| INHIBITORY_SYNAPSE | disrupts | gene | 0.80 |
| C3AR | interacts_with | protein | 0.72 |
| MICROGLIA | activates | cell_type | 0.64 |
| COGNITIVE_IMPAIRMENT | associated_with | phenotype | 0.64 |
| M2_POLARIZATION | activates | phenotype | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Astrocyte C3aR Signaling as Bifurcation Point for A1/A2 Fate | 0.750 | Alzheimer's disease, Parkinson's disease | - |
| C3aR Blockade Disrupts the Microglial-Astrocyte Feedforward | 0.633 | neuroinflammation | What molecular mechanisms determine whet |
| Complement Cascade Specificity: Microglial C3aR Antagonism D | 0.618 | synaptic biology | Does SPP1-mediated synaptic engulfment r |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity