gene 908 words KG: BAK1
Contents

BAK1 Gene

🧬 Gene Info
Gene SymbolBAK1
Full NameBCL2-Antagonist/Killer 1
Chromosome6p21.31
Protein TypeBCL2 family (pro-apoptotic)
FunctionBAK1 is a 25 kDa protein localized primarily to the mitochondrial outer membrane
Molecular Weight25 kDa
PathwaysFerroptosis, Mtor, Necroptosis, Pyroptosis, apoptosis
UniProt IDQ9YM15
NCBI Gene ID578
Ensembl IDENSG00000130165
GeneCardsBAK1
Human Protein AtlasBAK1
Mitochondrial DynamicsRegulation of mitochondrial fission and fusion
[Autophagy](/entities/autophagy)Selective mitophagy through interaction with autophagy receptors
Cell Cycle RegulationCheckpoint control in response to DNA damage
Associated DiseasesAls, oxidative stress, OXIDATIVE_STRESS, Tumor
InteractionsAMBRA1, ATP, BAX, BCL2, BECN1, BNIP3
KG Connections148 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (8)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.78
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64

Related Analyses (5)

Senescent cell clearance as neurodegeneration therapy
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Apoptosis in Neurodegeneration
entity · KG edge: biomarker_for
BAX Gene
gene · KG edge: associated_with
BCL2L1 Gene
gene · KG edge: biomarker_for
BID — BH3 Interacting Domain Death Agonist
gene · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: regulates

Knowledge Graph (12 edges)

FAS regulates BAK1
MMP1 regulates BAK1
BAK1 biomarker_for BCL2L1
BID associated_with BAK1
BAK1 associated_with BAX
BAK1 activates MTOR
BCL2L1 biomarker_for BAK1
MTOR activates BAK1
BAX associated_with BAK1
BAK1 regulates FAS

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