concept

P16INK4A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P16INK4A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

50Connections

0Hypotheses

2Analyses

33Outgoing

17Incoming

0Experiments

4Debates

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💡 Concept Info

Name	P16INK4A
Key Genes/Proteins	AGING, ALZHEIMER, AND, APOPTOSIS, App, ATM
Related Diseases	Aging, Als, ALS, Alzheimer, Ataxia
Related Pathways	Apoptosis

Pathway Diagram

graph TD
    P16INK4A["P16INK4A"]
    P16INK4A -->|"activates"| senescence["senescence"]
    P16INK4A -->|"regulates"| Aging["Aging"]
    P16INK4A -->|"regulates"| Obesity["Obesity"]
    P16INK4A -->|"regulates"| Inflammation["Inflammation"]
    P16INK4A -->|"regulates"| Diabetes["Diabetes"]
    P16INK4A -->|"regulates"| Alzheimer["Alzheimer"]
    P16INK4A -->|"regulates"| ALS["ALS"]
    P16INK4A -.biomarker for.-> Senescence["Senescence"]
    GSK3B["GSK3B"] -->|"binds"| P16INK4A
    RB1["RB1"] -->|"regulates"| P16INK4A
    APOPTOSIS["APOPTOSIS"] -.biomarker for.-> P16INK4A
    ALZHEIMER["ALZHEIMER"] -->|"regulates"| P16INK4A
    GENES["GENES"] -->|"regulates"| P16INK4A
    BCL2L1["BCL2L1"] -.biomarker for.-> P16INK4A
    CDKN2A["CDKN2A"] -->|"activates"| P16INK4A
    TP53["TP53"] -->|"activates"| P16INK4A

Outgoing (33)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:P16INK4A	data_in	dataset_row	0.00
senescence	activates	pathway	0.85
Cancer	activates	disease	0.65
Ataxia	activates	disease	0.65
Als	regulates	disease	0.65
Senescence	biomarker_for	disease	0.65
Aging	regulates	disease	0.65
Obesity	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
ALS	regulates	disease	0.65
APOPTOSIS	biomarker_for	gene	0.60
Apoptosis	biomarker_for	pathway	0.60
T Cell	regulates	cell_type	0.60
DNA	activates	gene	0.60
ATM	activates	gene	0.60
Dna Repair	activates	pathway	0.60
Ras	regulates	protein	0.60
P21	biomarker_for	protein	0.60
GENES	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
P21CIP1	biomarker_for	gene	0.60
Rb	regulates	protein	0.60
INFLAMMATION	regulates	gene	0.60
BCL2L1	biomarker_for	gene	0.60
BAK1	biomarker_for	gene	0.60
MMP1	regulates	gene	0.60
AGING	regulates	gene	0.60
AND	biomarker_for	gene	0.60
FAS	regulates	gene	0.60
App	regulates	protein	0.60
T Cell	expressed_in	cell_type	0.55

Incoming (17)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:P16INK4A	data_in	dataset_row	0.00
RB1	regulates	gene	0.70
APOPTOSIS	biomarker_for	gene	0.60
AGING	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
FAS	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
GENES	regulates	gene	0.60
BCL2L1	biomarker_for	gene	0.60
CDKN2A	activates	gene	0.60
TP53	activates	gene	0.60
P53	activates	gene	0.60
CANCER	activates	gene	0.60
GENES	activates	gene	0.60
P21CIP1	biomarker_for	gene	0.60
MMP1	regulates	gene	0.60
BAK1	biomarker_for	gene	0.60