concept

PI3K/AKT PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K/AKT PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

200Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	PI3K/AKT PATHWAY
Key Genes/Proteins	AKT, AMYLOID, AXL, BAX, BDNF, CLU
Related Diseases	ANGIOGENESIS, APOPTOSIS, cancer, CELL SURVIVAL, CERAMIDE

Pathway Diagram

graph TD
    PI3K_AKT_PATHWAY["PI3K/AKT PATHWAY"]
    style PI3K_AKT_PATHWAY fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    PI3K_AKT_PATHWAY -->|"mediates"| Cancer_Metabolism_Reprogrammin["Cancer Metabolism Reprogramming"]
    PI3K_AKT_PATHWAY -->|"promotes"| breast_cancer_drug_resistance(breast cancer drug resistance)
    PI3K_AKT_PATHWAY -->|"activates"| NRF2([NRF2])
    PI3K_AKT_PATHWAY -->|"phosphorylates"| GLUT1([GLUT1])
    PI3K_AKT_PATHWAY -->|"phosphorylates"| HK2["HK2"]
    PI3K_AKT_PATHWAY -->|"phosphorylates"| PKM2["PKM2"]
    PI3K_AKT_PATHWAY -->|"regulates"| Vascular_Barrier_Function(Vascular Barrier Function)
    PI3K_AKT_PATHWAY -->|"promotes"| TNBC_cell_proliferation["TNBC cell proliferation"]
    PI3K_AKT_PATHWAY -->|"causes"| Cancer_Metabolism(Cancer Metabolism)
    PI3K_AKT_PATHWAY -->|"regulates"| mTORC1([mTORC1])
    nomilin{"nomilin"} -.->|"inhibits"| PI3K_AKT_PATHWAY
    hesperetin{"hesperetin"} -->|"activates"| PI3K_AKT_PATHWAY
    SQDS{"SQDS"} -.->|"inhibits"| PI3K_AKT_PATHWAY
    PI3K_Inhibitor{"PI3K Inhibitor"} -.->|"inhibits"| PI3K_AKT_PATHWAY
    quinolinic_acid["quinolinic acid"] -->|"activates"| PI3K_AKT_PATHWAY
    ANGPT1([ANGPT1]) -->|"activates"| PI3K_AKT_PATHWAY
    TREM1["TREM1"] -->|"activates"| PI3K_AKT_PATHWAY
    REEP1([REEP1]) -->|"regulates"| PI3K_AKT_PATHWAY
    MYC([MYC]) -->|"regulates"| PI3K_AKT_PATHWAY
    TREM2([TREM2]) -->|"activates"| PI3K_AKT_PATHWAY

Outgoing (118)

Target	Relation	Type	Str
Aerobic Glycolysis	associated_with	process	0.95
Cancer	associated_with	disease	0.95
Cancer Metabolism Reprogramming	mediates	process	0.95
Aerobic Glycolysis	promotes	process	0.95
breast cancer drug resistance	promotes	phenotype	0.95
Cancer	associated_with	disease	0.92
TNBC cell proliferation	promotes	process	0.90
Cancer	drives	disease	0.90
GLUT1	phosphorylates	gene	0.90
Cancer Metabolism	causes	phenotype	0.90
glucose metabolism	regulates	process	0.90
CANCER	implicated_in	disease	0.90
NRF2	activates	protein	0.90
PFKFB3	phosphorylates	gene	0.90
HER2-positive breast cancer	associated_with	disease	0.90
Cancer Metabolism	modulates	process	0.90
GLUT1	phosphorylates	protein	0.90
Aβ-Induced Cytotoxicity	protects_against	phenotype	0.90
PKM2	phosphorylates	gene	0.90
HK2	phosphorylates	gene	0.90
Vascular Barrier Function	regulates	phenotype	0.90
triple negative breast cancer	upstream_of	disease	0.88
TNBC Cell Proliferation	regulates	process	0.88
mTORC1	regulates	protein	0.88
MTOR	regulates	protein	0.85
depression	modulates	disease	0.85
FOXO	regulates	gene	0.85
MYC	regulates	protein	0.85
Neuroprotection	mediates	process	0.85
neurogenesis	regulates	process	0.85
MEF2-HDAC Axis	interacts_with	mechanism	0.85
De Novo Lipid Synthesis	modulates	process	0.85
Vascular Barrier Function	mediates	phenotype	0.85
GSK3	regulates	gene	0.85
Pentose Phosphate Pathway	modulates	process	0.85
MYC	regulates	gene	0.85
De Novo Lipid Synthesis	modulates	process	0.85
Epithelial-Mesenchymal Transition	drives	process	0.85
MTOR	regulates	gene	0.85
MEF2	modulates	protein	0.85
HIF-1Α	regulates	protein	0.85
Blood-Brain Barrier Integrity	regulates	pathway	0.85
Vascular Barrier Function	mediates	phenotype	0.85
Pericyte Recruitment	mediates	process	0.85
HIF1A	regulates	gene	0.85
HIF-1α	regulates	protein	0.85
Pentose Phosphate Pathway	regulates	pathway	0.80
Redox Homeostasis	modulates	process	0.80
neuroinflammation	modulates	process	0.80
coronary heart disease	causes	disease	0.80

Incoming (82)

Source	Relation	Type	Str
nomilin	inhibits	drug	0.95
Apremilast	activates	drug	0.95
quinolinic acid	activates	metabolite	0.90
PI3K Inhibitor	inhibits	drug	0.90
PTEN	inhibits	gene	0.90
hesperetin	activates	drug	0.90
Nomilin	modulates	compound	0.90
PTEN	inhibits	gene	0.90
ANXA1	activates	protein	0.90
PI3K	part_of	gene	0.90
SQDS	inhibits	drug	0.90
ANGPT1	activates	protein	0.85
PDK1	inhibits	gene	0.85
PI3K	suppresses	gene	0.80
AKT1	part_of	gene	0.80
PI3K	interacts_with	gene	0.80
REEP1	regulates	gene	0.80
Ferroptosis	involved_in	process	0.75
MYC	regulates	gene	0.72
TBEV infection	perturbs	process	0.70
NEURON	stabilizes	cell_type	0.70
NEURON	treats	cell_type	0.70
NEURON	inhibits	cell_type	0.70
Acupuncture	regulates	process	0.70
TREM2	activates	protein	0.70
silibinin	inhibits	gene	0.70
PDGF	causes	gene	0.70
QKF	activates	drug	0.70
SCP-oil	activates	drug	0.70
merlin	regulates	protein	0.70
LY294002	inhibits	drug	0.70
SYK	causes	gene	0.70
BAX	activates	gene	0.65
CLU	activates	gene	0.65
SEPSIS	regulates	disease	0.65
ASTROCYTES	activates	cell_type	0.65
METASTASIS	activates	phenotype	0.65
METASTASIS	interacts_with	phenotype	0.65
METASTASIS	regulates	phenotype	0.65
SEPSIS	treats	disease	0.65
SODIUM BUTYRATE	regulates	drug	0.65
DAP12	activates	protein	0.50
Pi3K	associated_with	pathway	0.50
cancer	associated_with	disease	0.50
Pi3K/Akt	associated_with	pathway	0.50
Pi3K	activates	pathway	0.50
cancer	activates	disease	0.50
Pi3K/Akt	activates	pathway	0.50
Pi3K	interacts_with	pathway	0.50
Pi3K/Akt	interacts_with	pathway	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PI3K/AKT PATHWAY in their description or question text

No additional research found