concept

SREBP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SREBP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

409Connections

3Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

SREBP2 is a concept in neurodegeneration research. Key relationships include: activates, regulates, interacts with. Associated with ALS, Als, Alzheimer. Connected to 105 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	SREBP2
Key Genes/Proteins	ABCA1, ABCA7, Actin, AGING, AIM2, AKT
Related Diseases	aging, Aging, Als, ALS, Alzheimer
Related Pathways	Adaptive Immunity
Linked Hypotheses	3 hypotheses

Pathway Diagram

graph TD
    SREBP2["SREBP2"]
    SREBP2 -->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    SREBP2 -->|"interacts"| Als["Als"]
    SREBP2 -->|"interacts"| Autoimmune["Autoimmune"]
    SREBP2 -->|"activates"| Carcinoma["Carcinoma"]
    SREBP2 -->|"target for"| Cancer["Cancer"]
    SREBP2 -->|"target for"| Tumor["Tumor"]
    SREBP2 -->|"target for"| Ms["Ms"]
    GPR146["GPR146"] -->|"activates"| SREBP2
    ERK["ERK"] -->|"activates"| SREBP2
    CGAS["CGAS"] -->|"interacts"| SREBP2
    LDLR["LDLR"] -->|"activates"| SREBP2
    NLRP3["NLRP3"] -->|"activates"| SREBP2
    CANCER["CANCER"] -->|"target for"| SREBP2
    CASP3["CASP3"] -->|"target for"| SREBP2

Outgoing (250)

Target	Relation	Type	Str
VLDL Secretion	regulates	process	0.90
Cholesterol	activates	pathway	0.90
BACE1	regulates	protein	0.87
Inflammation	activates	disease	0.85
cholesterol homeostasis	regulates	process	0.85
Lipid Droplet Accumulation	promotes	process	0.80
Lipid Metabolism	activates	pathway	0.70
Inflammasome	activates	pathway	0.70
lipid metabolism	participates_in	pathway	0.70
neurons	expressed_in	cell_type	0.70
Lipid Metabolism	regulates	pathway	0.70
Cholesterol	regulates	pathway	0.70
INFLAMMATION	activates	gene	0.70
Autoimmune	interacts_with	disease	0.65
Parkinson	regulates	disease	0.65
Atherosclerosis	inhibits	disease	0.65
ALS	causes	disease	0.65
Cardiovascular	regulates	disease	0.65
Aging	inhibits	disease	0.65
Atherosclerosis	protects_against	disease	0.65
Sepsis	activates	disease	0.65
Alzheimer	causes	disease	0.65
Cancer	regulates	disease	0.65
Als	interacts_with	disease	0.65
Aging	associated_with	disease	0.65
Als	contributes_to	disease	0.65
Diabetes	regulates	disease	0.65
Cancer	causes	disease	0.65
Alzheimer	inhibits	disease	0.65
Atherosclerosis	regulates	disease	0.65
Arrhythmia	regulates	disease	0.65
Glioblastoma	regulates	disease	0.65
Tumor	causes	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	interacts_with	disease	0.65
Inflammation	regulates	disease	0.65
Als	activates	disease	0.65
Alzheimer	activates	disease	0.65
ALS	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Carcinoma	activates	disease	0.65
ALS	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Aging	encodes	disease	0.65
Neuroinflammation	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Autoimmune	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Diabetes	inhibits	disease	0.65

Incoming (159)

Source	Relation	Type	Str
SCAP	interacts_with	gene	0.90
TNF	activates	protein	0.90
NPC1	interacts_with	protein	0.85
ERK Signaling Pathway	activates	pathway	0.85
ER stress	activates	process	0.80
STING	interacts_with	entity	0.80
GPR146	activates	protein	0.72
LDLR	activates	gene	0.70
LDL	regulates	gene	0.70
ERK	activates	protein	0.64
NPC1	associated_with	gene	0.60
NLRP3	activates	gene	0.60
CANCER	therapeutic_target	gene	0.60
CASP3	therapeutic_target	gene	0.60
MICROGLIA	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
APOE4	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
NF-ΚB	activates	gene	0.60
APOE	activates	gene	0.60
TAU	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
MIR-9-5P	regulates	gene	0.60
ATF6	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
CHOP	interacts_with	gene	0.60
LDLR	inhibits	gene	0.60
GENES	inhibits	gene	0.60
DNA	interacts_with	gene	0.60
LYSOSOME	interacts_with	gene	0.60
NPC1	transports	gene	0.60
STING	transports	gene	0.60
APOE	regulates	gene	0.60
SREBP1	implicated_in	gene	0.60
ATP	inhibits	gene	0.60
APOE	inhibits	gene	0.60
INFLAMMATION	regulates	gene	0.60
DYNEIN	activates	gene	0.60
GSK3	inhibits	gene	0.60
ERK	regulates	gene	0.60
STING	associated_with	gene	0.60
CGAS	interacts_with	gene	0.60
GPR146	regulates	gene	0.60
CGAS	activates	gene	0.60
ABCA1	inhibits	gene	0.60
RNA	regulates	gene	0.60
EGFR	regulates	gene	0.60
LPL	expressed_in	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
APOE4-driven lysosome-to-ER cholesterol transport failure re	0.690	molecular biology	Does APOE4's reduced lipid-binding direc
Upstream restoration of glial lipid efflux and apoE lipidati	0.590	molecular biology	Does APOE4's reduced lipid-binding direc
APOE4-associated inflammatory signaling amplifies SREBP2 act	0.470	molecular biology	Does APOE4's reduced lipid-binding direc

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does APOE4's reduced lipid-binding directly modulate SREBP2-SCAP complex retenti

molecular biology | 2026-04-24 | 6 hypotheses Top: 0.690

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Does APOE4's reduced lipid-binding directly modulate SREBP2-SCAP complex retenti

active · Rounds: 4 · Score: 0.58 · 2026-04-24

Related Research

Hypotheses and analyses mentioning SREBP2 in their description or question text

No additional research found