gene

GPR146

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GPR146: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

48Connections

0Hypotheses

0Analyses

38Outgoing

10Incoming

0Experiments

0Debates

Summary

GPR146 (G protein-coupled receptor 146) is a class A GPCR involved in lipid metabolism, energy homeostasis, and brain function. Genetic variants are associated with altered lipid profiles and metabolic syndrome, with emerging links to Alzheimer's disease through metabolic dysfunction.

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🧬 Gene Info

Gene Symbol	GPR146
Full Name	G Protein-Coupled Receptor 146
Chromosome	7q31.33
Protein Type	Receptor
Function	GPR146 signals through G proteins to regulate metabolic pathways:
Primary Expression	metabolic tissues and the brain
Pathways	MAPK pathway, PI3K
UniProt ID	Q96CH4
NCBI Gene ID	115329
Ensembl ID	ENSG00000173334
GeneCards	GPR146
Human Protein Atlas	GPR146
Gα_s coupling	Activates adenylate cyclase, increasing cAMP levels
Gα_i coupling	Inhibits adenylate cyclase in certain cell types
β-arrestin signaling	Engages downstream effectors through β-arrestin recruitment
Associated Diseases	atherosclerosis, Cardiovascular
Interactions	AND, ERK, GENES, LDL, LDLR, LDL RECEPTOR
KG Connections	48 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GPR146 — AlphaFold Q96CH4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GPR146 — G Protein-Coupled Receptor 146

gene · 926 words

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Pathway Diagram

graph TD
    GPR146["GPR146"]
    SREBP2["SREBP2"]
    GPR146 -->|"activates"| SREBP2
    ERK["ERK"]
    GPR146 -->|"activates"| ERK
    cholesterol_metabolism(["cholesterol_metabolism"])
    GPR146 -->|"regulates"| cholesterol_metabolism
    Atherosclerosis{"Atherosclerosis"}
    GPR146 -->|"inhibits"| Atherosclerosis
    VLDL["VLDL"]
    GPR146 -->|"regulates"| VLDL
    LDL_C["LDL-C"]
    GPR146 -->|"regulates"| LDL_C
    triglycerides["triglycerides"]
    GPR146 -->|"regulates"| triglycerides
    atherosclerosis{"atherosclerosis"}
    GPR146 -->|"activates"| atherosclerosis
    LDLR["LDLR"]
    GPR146 -->|"inhibits"| LDLR
    Cholesterol(["Cholesterol"])
    GPR146 -->|"regulates"| Cholesterol
    GPR146 -->|"regulates"| SREBP2
    Cholesterol_Metabolism(["Cholesterol Metabolism"])
    GPR146 -->|"inhibits"| Cholesterol_Metabolism
    ERK -->|"regulates"| GPR146
    SREBP2 -->|"regulates"| GPR146
    GENES["GENES"]
    GENES -->|"inhibits"| GPR146
    LDLR -->|"inhibits"| GPR146
    LDL["LDL"]
    LDL -->|"regulates"| GPR146
    AND["AND"]
    AND -->|"inhibits"| GPR146
    style GPR146 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (38)

Target	Relation	Type	Str
SREBP2	activates	protein	0.72
ERK	activates	protein	0.72
cholesterol_metabolism	regulates	pathway	0.72
Cardiovascular	implicated_in	disease	0.65
Atherosclerosis	inhibits	disease	0.65
LDL-C	regulates	protein	0.64
triglycerides	regulates	protein	0.64
VLDL	regulates	protein	0.64
atherosclerosis	activates	disease	0.64
LDL	associated_with	gene	0.60
oxidative stress response	participates_in	pathway	0.60
lipid metabolism	participates_in	pathway	0.60
cardiovascular disease	inhibits	disease	0.60
LDL	inhibits	gene	0.60
LDL	activates	gene	0.60
Cholesterol	regulates	pathway	0.60
AND	inhibits	gene	0.60
GENES	inhibits	gene	0.60
SURF4	implicated_in	gene	0.60
Cholesterol Metabolism	inhibits	pathway	0.60
ERK	regulates	gene	0.60
LDLR	inhibits	gene	0.60
LDLR	associated_with	entity	0.60
SREBP2	regulates	gene	0.60
Cholesterol	implicated_in	pathway	0.60
Lipid Metabolism	implicated_in	pathway	0.60
LDL	regulates	gene	0.60
hypercholesterolemia	activates	disease	0.56
LDLR	co_expressed_with	gene	0.50
VLDL	co_expressed_with	protein	0.50
LDL RECEPTOR	inhibits	protein	0.50
Cholesterol	inhibits	pathway	0.50
atherosclerosis	inhibits	disease	0.50
CHOLESTEROL METABOLISM	inhibits	concept	0.50
Cholesterol	decreases_risk	pathway	0.50
atherosclerosis	decreases_risk	disease	0.50
VLDL	activates	protein	0.50
Cholesterol	activates	pathway	0.50

Incoming (10)

Source	Relation	Type	Str
GENES	implicated_in	gene	0.60
AND	inhibits	gene	0.60
LDLR	inhibits	gene	0.60
ERK	activates	gene	0.60
ERK	inhibits	gene	0.60
ERK	regulates	gene	0.60
SREBP2	regulates	gene	0.60
GENES	inhibits	gene	0.60
LDL	regulates	gene	0.60
ERK	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GPR146 in their description or question text

No additional research found