concept

CTLA4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CTLA4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

48Connections

0Hypotheses

0Analyses

34Outgoing

14Incoming

0Experiments

0Debates

No summary available yet.

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💡 Concept Info

Name	CTLA4
Key Genes/Proteins	ABCB1, ALDH1A1, AMPK, AND, ATF3, AXIN2
Related Diseases	autoimmunity, cancer, Cancer

Pathway Diagram

graph TD
    CTLA4["CTLA4"]
    CTLA4 -->|"regulates"| Immune_Homeostasis["Immune Homeostasis"]
    CTLA4 -->|"expressed in"| CD4__T_Cell["CD4+ T Cell"]
    CTLA4 -->|"inhibits"| T_Cell_Activation["T Cell Activation"]
    CTLA4 -->|"inhibits"| Tumor["Tumor"]
    CTLA4 -->|"inhibits"| Cancer["Cancer"]
    CTLA4 -->|"inhibits"| Immune_Response["Immune Response"]
    CTLA4 -->|"inhibits"| T_Cell["T Cell"]
    CTLA4 -->|"inhibits"| AND["AND"]
    AND -->|"inhibits"| CTLA4
    CANCER["CANCER"] -->|"inhibits"| CTLA4

Outgoing (34)

Target	Relation	Type	Str
immune homeostasis	involved_in	process	0.90
autoimmunity	risk_factor_for	disease	0.80
T Cell Activation	inhibits	process	0.70
Tumor	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Immune Response	inhibits	pathway	0.60
cancer	inhibits	disease	0.60
CANCER	inhibits	gene	0.60
AND	inhibits	gene	0.60
PD1	inhibits	gene	0.60
T Cell	associated_with	cell_type	0.60
DKK1	targets	gene	0.60
EOMES	targets	gene	0.60
FGF18	targets	gene	0.60
FGF20	targets	gene	0.60
FZD7	targets	gene	0.60
IL10	targets	gene	0.60
JAG1	targets	gene	0.60
LEF1	targets	gene	0.60
MITF	targets	gene	0.60
MYC	targets	gene	0.60
NEUROD1	targets	gene	0.60
NOTCH2	targets	gene	0.60
NRCAM	targets	gene	0.60
PPARD	targets	gene	0.60
PTGS2	targets	gene	0.60
SNAI1	targets	gene	0.60
TERT	targets	gene	0.60
TNFRSF19	targets	gene	0.60
T Cell	inhibits	cell_type	0.60
VEGFA	targets	gene	0.60
Raf	inhibits	protein	0.60
T Cell	expressed_in	cell_type	0.55
PD-L1	inhibits	gene	0.35

Incoming (14)

Source	Relation	Type	Str
AMPK	inhibits	gene	0.60
CD38	associated_with	gene	0.60
CD4	associated_with	gene	0.60
PD-1	associated_with	gene	0.60
CLDN1	targets	gene	0.60
ABCB1	targets	gene	0.60
ALDH1A1	targets	gene	0.60
ATF3	targets	gene	0.60
AXIN2	targets	gene	0.60
BAMBI	targets	gene	0.60
CCND1	targets	gene	0.60
CD44	targets	gene	0.60
CANCER	associated_with	disease	0.45
CANCER	inhibits	disease	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CTLA4 in their description or question text

No additional research found