Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CD31: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CD31 |
| Key Genes/Proteins | ACTB, ANGPT1, ANXA5, BECN1, BMP2, CD68 |
| Related Pathways | autophagy pathway |
| Linked Hypotheses | 1 hypotheses |
graph TD
CD31[CD31]
CD31 -->|involved_in| Angiogenesis[Angiogenesis]
CD31 -->|involved_in| Vessel_Formation[Vessel Formation]
CD31 -->|expressed in| endothelial_cells[endothelial cells]
CD31 -->|expressed in| CD68[CD68]
CD31 -->|expressed in| GFAP[GFAP]
CD31 -->|expressed in| S100A8[S100A8]
CD31 -->|expressed in| VEGFA[VEGFA]
CD31 -->|activates| VEGF[VEGF]
CD31 -->|expressed in| FGF2[FGF2]
Irisin[Irisin] -->|upregulates| CD31
BMP2[BMP2] -->|activates| CD31
ANGPT1[ANGPT1] -->|expressed in| CD31
ACTB[ACTB] -->|regulates| CD31
BECN1[BECN1] -->|regulates| CD31
ANXA5[ANXA5] -->|regulates| CD31
benchmark_ot_ad_answer_key_CD3[benchmark_ot_ad_answer_key:CD31] -->|data_in| CD31| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:CD31 | data_in | dataset_row | 0.00 |
| Angiogenesis | involved_in | process | 0.90 |
| endothelial cells | expressed_in | cell_type | 0.80 |
| Vessel Formation | involved_in | process | 0.80 |
| endothelial microparticles | biomarker_for | cell_type | 0.70 |
| pyroptosis | participates_in | pathway | 0.60 |
| PCNA | associated_with | gene | 0.60 |
| RUNX2 | biomarker_for | gene | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| MAP1LC3 | regulates | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| EPO | activates | gene | 0.60 |
| HIF | expressed_in | gene | 0.60 |
| VEGFA | expressed_in | gene | 0.60 |
| VEGFA | activates | gene | 0.60 |
| GSDME | associated_with | gene | 0.60 |
| NLRP3 | associated_with | gene | 0.60 |
| VEGF | activates | gene | 0.60 |
| FGF2 | expressed_in | gene | 0.60 |
| PDGFRB | expressed_in | gene | 0.60 |
| PICALM | expressed_in | gene | 0.60 |
| DLL4 | biomarker_for | gene | 0.60 |
| NOTCH1 | biomarker_for | gene | 0.60 |
| VEGFA | biomarker_for | gene | 0.60 |
| CD68 | expressed_in | gene | 0.60 |
| GFAP | expressed_in | gene | 0.60 |
| S100A8 | expressed_in | gene | 0.60 |
| GFAP | associated_with | gene | 0.60 |
| CKB | regulates | gene | 0.60 |
| CTS | regulates | gene | 0.60 |
| GAPDH | regulates | gene | 0.60 |
| GATA3 | regulates | gene | 0.60 |
| GLB1 | regulates | gene | 0.60 |
| IL1RL1 | regulates | gene | 0.60 |
| IL4 | regulates | gene | 0.60 |
| IL7R | regulates | gene | 0.60 |
| LC3 | regulates | gene | 0.60 |
| LDH | regulates | gene | 0.60 |
| PECAM1 | regulates | gene | 0.60 |
| RORC | regulates | gene | 0.60 |
| SQSTM1 | regulates | gene | 0.60 |
| TNF | regulates | gene | 0.60 |
| VIM | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Circulating Endothelial Microparticles Expressing Activated | 0.565 | - | What blood-brain barrier permeability ch |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.940
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning CD31 in their description or question text
No additional research found