protein

NSF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NSF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

108Connections
18Hypotheses
0Analyses
50Outgoing
38Incoming
20Experiments
0Debates

Summary

NSF is a protein involved in neurodegeneration research. Key relationships include: associated with, regulates, interacts with. Associated with Als, Cancer, Glioma. Connected to 54 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolNSF
Full NameN-Ethylmaleimide Sensitive Fusion Protein
Chromosome17q21.31
FunctionNSF is a member of the AAA+ (ATPases Associated with diverse cellular Activities) protein family that functions as a molecular chaperone for SNARE complex recycling
Primary Expressionall eukaryotic cells, with high expression in neurons - Protein Complexes: Forms hexameric complexes and interacts with alpha
Molecular Weight66 kDa
PathwaysApoptosis, Cell Cycle
UniProt IDP46459
NCBI Gene ID4900
Ensembl IDENSG00000134574
OMIM163580
GeneCardsNSF
Human Protein AtlasNSF
Associated Diseasesepilepsy
Known Drugs/Compoundsrapamycin
InteractionsAMPK, AND, LC3, MAP1LC3, MTOR, MTORC1
KG Connections108 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: NSF — AlphaFold P46459 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

NSF Gene

gene · 612 words

NAPA — NSF Attachment Protein Alpha

gene · 993 words

NSF Protein

protein · 953 words

alpha-SNAP Protein (NSF Attachment Protein Alpha)

protein · 635 words

Pathway Diagram

graph TD
    NSF["NSF"]
    Cancer{"Cancer"}
    NSF -->|"regulates"| Cancer
    Tumor{"Tumor"}
    NSF -->|"regulates"| Tumor
    Glioma{"Glioma"}
    NSF -->|"regulates"| Glioma
    Als{"Als"}
    NSF -->|"regulates"| Als
    Ms{"Ms"}
    NSF -->|"regulates"| Ms
    Stroke{"Stroke"}
    NSF -->|"interacts with"| Stroke
    LAMP1["LAMP1"]
    NSF -->|"associated with"| LAMP1
    ATG12["ATG12"]
    NSF -->|"associated with"| ATG12
    Mtor(["Mtor"])
    NSF -->|"associated with"| Mtor
    Autophagy(["Autophagy"])
    NSF -->|"associated with"| Autophagy
    GAPDH["GAPDH"]
    NSF -->|"associated with"| GAPDH
    STX17["STX17"]
    NSF -->|"associated with"| STX17
    VAMP8["VAMP8"]
    VAMP8 -->|"associated with"| NSF
    ULK1["ULK1"]
    ULK1 -->|"associated with"| NSF
    LC3["LC3"]
    LC3 -->|"associated with"| NSF
    MCOLN1["MCOLN1"]
    MCOLN1 -->|"associated with"| NSF
    GAPDH -->|"associated with"| NSF
    STX17 -->|"associated with"| NSF
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"associated with"| NSF
    MAP1LC3["MAP1LC3"]
    MAP1LC3 -->|"associated with"| NSF
    P62["P62"]
    P62 -->|"associated with"| NSF
    ATG12 -->|"associated with"| NSF
    STX17 -->|"contributes to"| NSF
    MIRNAS["MIRNAS"]
    MIRNAS -->|"regulates"| NSF
    style NSF fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (70)

TargetRelationTypeStr
SNCAexpressesgene0.70
Alzheimerbiomarker_fordisease0.65
Inflammationbiomarker_fordisease0.65
Msbiomarker_fordisease0.65
Alsbiomarker_fordisease0.65

Incoming (38)

SourceRelationTypeStr
KEAP1expressesgene0.70
LYSOSOMEregulatesgene0.60
MTORC1associated_withgene0.60
MITOPHAGYprotects_againstpathway0.60
MIRNASregulatesgene0.60

Targeting Hypotheses (18)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
pH-Sensitive Bispecific Antibody Targeting Transferrin Recep 0.800 neurodegeneration Blood-brain barrier antibody transport m
Magnetosonic-Triggered Transferrin Receptor Clustering 0.719 neurodegeneration Blood-brain barrier transport mechanisms
Mitochondrial Transfer Pathway Enhancement 0.695 neurodegeneration Astrocyte reactivity subtypes in neurode
Endosomal escape determines whether transferred tau becomes 0.694 neurodegeneration Seed-competent tau conformers in trans-s
CX43 hemichannel engineering enables size-selective mitochon 0.686 neurodegeneration Mitochondrial transfer between astrocyte
GAP43-mediated tunneling nanotube stabilization enhances neu 0.666 neurodegeneration Mitochondrial transfer between astrocyte
whether the Mitochondrial transfer between neurons and glia 0.604 neurodegeneration Methodology challenge: notebook 'Mitocho
whether the Mitochondrial transfer between neurons and glia 0.604 neurodegeneration Methodology challenge: notebook 'Mitocho
Stratified falsifiers should govern Methodology challenge: n 0.591 neurodegeneration Methodology challenge: notebook 'Mitocho
Stratified falsifiers should govern Methodology challenge: n 0.591 neurodegeneration Methodology challenge: notebook 'Mitocho
Mitochondrial transfer between neurons and glia — Rich Analy 0.577 neurodegeneration Methodology challenge: notebook 'Mitocho
Mitochondrial transfer between neurons and glia — Rich Analy 0.577 neurodegeneration Methodology challenge: notebook 'Mitocho
Extracellular Vesicle Cargo Transfer 0.480 neurodegeneration Which specific factors in conditioned me
Optogenetic Control of Mitochondrial Transfer Networks 0.476 neurodegeneration Mitochondrial transfer between neurons a
Glycosyltransferase Modulation for Tau Vesicle Marking 0.455 neurodegeneration Do tau-containing vesicles exhibit uniqu
Transferrin-Alectinib Conjugation Enhances Blood-Brain Barri 0.406 molecular biology Does Alectinib truly bind C1q directly w
Astrocyte CD38-erk Mapk signaling controls mitochondrial tra 0.380 ALS and Alzheimer's disease Mitochondrial transfer between neurons a
Enhancing Heparan Sulfate 3-O-Sulfotransferase Activity to C 0.380 neuroscience Trans-synaptic tau spreading and propaga

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (20)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
Autophagy receptor identification for stress granule elimination exploratory neurodegenerative diseases 0.900 0.00 cultured cells under arsenite proposed N/A
iPSC-derived endothelial cell iron uptake with RLS CSF exposure exploratory restless legs syndrome 0.900 0.00 iPSC-derived human endothelial proposed N/A
Cx43 knockdown effects on mitochondrial transfer exploratory osteoarthritis 0.900 0.00 human bone marrow-derived MSCs proposed N/A
Confocal imaging of MSC-chondrocyte interactions during mitochondrial exploratory osteoarthritis 0.850 0.00 human bone marrow-derived MSCs proposed N/A
s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice with engin falsification Neuroinflammation 0.400 0.50 mouse proposed $200,000
s:** - Compare uptake with/without magnetic particles using tight junc falsification Neurodegeneration 0.400 0.50 cell_line proposed $120,000
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Therapy validation Parkinson's Disease 0.400 0.50 mouse proposed $280,000
AAV Serotype Comparison for LRRK2 Knockdown in PD validation Parkinson's Disease 0.400 0.50 mouse proposed $280,000
s:** - Test MCU overexpression specifically in layer II neurons in hea falsification Neurodegeneration 0.400 0.50 mouse proposed $200,000
Proposed experiment from debate on Mitochondrial transfer between astr falsification Neurodegeneration 0.400 0.50 cell_line proposed $80,000
Proposed experiment from debate on Mitochondrial transfer between astr falsification Neurodegeneration 0.400 0.50 cell_line proposed $100,000
Mechanism: Selective Vulnerability of Dopaminergic Neurons in Parkinso validation Parkinson's Disease 0.400 0.50 human proposed $3,000,000
Selective Vulnerability of Dopaminergic Neurons — Mechanism and Protec validation Neurodegeneration 0.400 0.50 cell_line proposed $160,000
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment Design clinical Parkinson's Disease 0.400 0.50 human proposed $7,500,000
Exercise-BDNF-Mitophagy Biomarker Study in PD clinical Parkinson's Disease 0.400 0.50 human proposed $6,550,000
Ferroptosis Validation in Parkinson's Disease clinical Parkinson's Disease 0.400 0.50 human proposed $6,550,000
GLP-1 Agonist Neuroprotection Mechanism in PD clinical Parkinson's Disease 0.400 0.50 human proposed $6,550,000
Cytochrome Therapeutics clinical Parkinson's Disease 0.400 0.50 human proposed $5,460,000
AAV-LRRK2 IND-Enabling Study Design clinical Parkinson's Disease 0.400 0.50 human proposed $7,500,000
Gap Junction Dysfunction Validation in Parkinson's Disease clinical Alzheimer's Disease 0.400 0.50 human proposed $5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic t [PMID:32048886] Yao RQ, Ren C, Xia ZF, Yao YM Autophagy 2021 2
Astrocytic Connexin43 in Alzheimer's disease: mechanisms, interaction with P2 re [PMID:41062060] Xiong W, Su Y, Verkhratsky A, Yi C Neuropharmacology 2026 1
Miro1: A potential target for treating neurological disorders. [PMID:40403957] Zeng L, Yang J, Zhang C, Zhu J, Zhong S, Neuroscience 2025 1
Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates co [PMID:40595567] Su Y, Li H, Zhang W, Tao S, Wang Q, Zhan Nat Commun 2025 1
Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease. [PMID:40425446] Sehlin D, Hultqvist G, Michno W, Aguilar J Prev Alzheimers Dis 2025 1
Calcium-Associated Proteins in Neuroregeneration. [PMID:38397420] Lisek M, Tomczak J, Boczek T, Zylinska L Biomolecules 2024 1
Should it stay or should it go: gap junction protein GJA1/Cx43 conveys damaged l [PMID:39394955] Domingues N, Ribeiro-Rodrigues T, Girão Autophagy 2024 1
Connexin 43 regulates intercellular mitochondrial transfer from human mesenchyma [PMID:39390589] Irwin RM, Thomas MA, Fahey MJ, Mayán MD, Stem Cell Res Ther 2024 1
Mitochondria from osteolineage cells regulate myeloid cell-mediated bone resorpt [PMID:38877020] Ding P, Gao C, Zhou J, Mei J, Li G, Liu Nat Commun 2024 1
Effect of ferroptosis on chronic cerebral hypoperfusion in vascular dementia. [PMID:37709116] Fu P, Chen Y, Wu M, Bao B, Yin X, Chen Z Exp Neurol 2023 1
Selective inhibition of cannabinoid CB(1) receptor-evoked signalling by the inte [PMID:37689260] Maroto IB, Moreno E, Costas-Insua C, Mer Neuropharmacology 2023 1
lncRNA LOC100911717-targeting GAP43-mediated sympathetic remodeling after myocar [PMID:36684596] Li P, Wang K, Yin J, Qi L, Hu H, Yang P, Front Cardiovasc Med 2022 1
Machine Learning and Novel Biomarkers for the Diagnosis of Alzheimer's Disease. [PMID:33803217] Chang CH, Lin CH, Lane HY Int J Mol Sci 2021 1
Astrocyte Networks as Therapeutic Targets in Glaucomatous Neurodegeneration. [PMID:34199470] Boal AM, Risner ML, Cooper ML, Wareham L Cells 2021 1
On Iron Metabolism and Its Regulation. [PMID:33925597] Vogt AS, Arsiwala T, Mohsen M, Vogel M, Int J Mol Sci 2021 1
MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote qualit [PMID:34873283] König T, Nolte H, Aaltonen MJ, Tatsuta T Nat Cell Biol 2021 1
Transferrin Receptor Is a Specific Ferroptosis Marker. [PMID:32160546] Feng H, Schorpp K, Jin J, Yozwiak CE, Ho Cell Rep 2020 1
Transferrin and transferrin receptors update. [PMID:29969719] Kawabata H Free Radic Biol Med 2019 1
Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal ste [PMID:24431222] Ahmad T, Mukherjee S, Pattnaik B, Kumar EMBO J 2014 1
Nerve growth cone motility. [PMID:2139335] Lankford K, Cypher C, Letourneau P Curr Opin Cell Biol 1990 1

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NSF in their description or question text

GAP43-mediated tunneling nanotube stabilization enhances neuroprotective mitocho

Score: 0.666 · neurodegeneration · 2026-04-02

## Mechanistic Overview GAP43-mediated tunneling nanotube stabilization enhances neuroprotective mitochondrial transfer

whether the Mitochondrial transfer between neurons and glia — Rich Analysis Note

Score: 0.604 · neurodegeneration · 2026-04-28

The debate supports carrying forward whether the Mitochondrial transfer between neurons and glia — Rich Analysis Noteboo

whether the Mitochondrial transfer between neurons and glia — Rich Analysis Note

Score: 0.604 · neurodegeneration · 2026-04-28

The debate supports carrying forward whether the Mitochondrial transfer between neurons and glia — Rich Analysis Noteboo

Stratified falsifiers should govern Methodology challenge: notebook 'Mitochondri

Score: 0.591 · neurodegeneration · 2026-04-28

Claims from this analysis should be evaluated across Methodology, challenge, Mitochondrial, transfer, between, neurons;

Stratified falsifiers should govern Methodology challenge: notebook 'Mitochondri

Score: 0.591 · neurodegeneration · 2026-04-28

Claims from this analysis should be evaluated across Methodology, challenge, Mitochondrial, transfer, between, neurons;

Mitochondrial transfer between neurons and glia — Rich Analysis Notebook should

Score: 0.577 · neurodegeneration · 2026-04-28

The consensus is to preserve this as a debated candidate, not a canonical world-model claim. Replication or rerun eviden

Mitochondrial transfer between neurons and glia — Rich Analysis Notebook should

Score: 0.577 · neurodegeneration · 2026-04-28

The consensus is to preserve this as a debated candidate, not a canonical world-model claim. Replication or rerun eviden

Extracellular Vesicle Cargo Transfer

Score: 0.480 · neurodegeneration · 2026-04-25

Healthy astrocytes release EVs containing protective cargo (potentially protein or RNA) that modifies recipient motor ne

Optogenetic Control of Mitochondrial Transfer Networks

Score: 0.476 · neurodegeneration · 2026-04-02

Light-activated ion channels in astrocytes trigger calcium influx that stimulates tunneling nanotube formation and mitoc

Glycosyltransferase Modulation for Tau Vesicle Marking

Score: 0.455 · neurodegeneration · 2026-04-27

Overexpression of specific glycosyltransferases (like MGAT5) creates 'glycan barcodes' on tau vesicles that recruit endo

Transferrin-Alectinib Conjugation Enhances Blood-Brain Barrier Transport via Tra

Score: 0.406 · molecular biology · 2026-04-21

## Mechanistic Overview Transferrin-Alectinib Conjugation Enhances Blood-Brain Barrier Transport via Transferrin Recepto

Astrocyte CD38-erk Mapk signaling controls mitochondrial transfer to neurons via

Score: 0.380 · ALS and Alzheimer's disease · 2026-04-27

Under neurodegenerative stress, astrocytes upregulate CD38, which triggers Erk MAPK signaling to promote tunneling nanot

Enhancing Heparan Sulfate 3-O-Sulfotransferase Activity to Competitively Block T

Score: 0.380 · neuroscience · 2026-04-26

The pathological spread of tau aggregates in Alzheimer's disease relies critically on heparan sulfate proteoglycan (HSPG