protein 953 words KG: NSFPROTEIN
Contents

NSF Protein

🔬 Protein Info
Gene SymbolNSF
Full NameN-Ethylmaleimide Sensitive Fusion Protein
Chromosome17q21.31
FunctionNSF is a member of the AAA+ (ATPases Associated with diverse cellular Activities) protein family that functions as a molecular chaperone for SNARE complex recycling
Primary Expressionall eukaryotic cells, with high expression in neurons - Protein Complexes: Forms hexameric complexes and interacts with alpha
Molecular Weight66 kDa
PathwaysApoptosis, Cell Cycle
UniProt IDP46459
NCBI Gene ID4900
Ensembl IDENSG00000134574
OMIM163580
GeneCardsNSF
Human Protein AtlasNSF
Associated Diseasesepilepsy
Known Drugs/Compoundsrapamycin
InteractionsAMPK, AND, LC3, MAP1LC3, MTOR, MTORC1
KG Connections108 knowledge graph edges
DatabasesGeneCardsHPASTRING

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UniProtWikipedia

Related Hypotheses (13)

AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Astrocytic Connexin-43 Upregulation Enhances Neuroprotective
Score: 0.56
Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy
Score: 0.55
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.53
VCP-Mediated Autophagy Enhancement
Score: 0.59
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (9)

Astrocyte Reactivity Subtypes in Neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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