gene

HNRNPA2B1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HNRNPA2B1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

417Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

10Experiments

2Debates

Summary

Page for HNRNPA2B1 - Heterogeneous Nuclear Ribonucleoprotein A2/B1

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🧬 Gene Info

Gene Symbol	HNRNPA2B1
Aliases	Page for HNRNPA2B1
Chromosome	7p15.2
Protein Family	HnRNP A/B family
Protein Type	Other
Target Class	Other
Function	Therapeutic agents targeting HNRNPA2B1 would work by modulating its RNA-binding activity, preventing pathological protein aggregation, or reducing the formation of cytoplasmic inclusions associated...
Mechanism of Action	Therapeutic agents targeting HNRNPA2B1 would work by modulating its RNA-binding activity, preventing pathological protein aggregation, or reducing the formation of cytoplasmic inclusions associated with neurodegeneration. These drugs could utilize antisense oligonucleotides to reduce HNRNPA2B1 expression or small molecules to inhibit its protein-protein interactions and RNA-binding functions.
Druggability	Low (0.35)
Clinical Stage	Phase II
Molecular Weight	36 kDa
Amino Acids	341 aa
Pathways	RNA transport / hnRNP processing
UniProt ID	P22626
NCBI Gene ID	3181
Ensembl ID	ENSG00000122566
OMIM	600124
GeneCards	HNRNPA2B1
Human Protein Atlas	HNRNPA2B1
Associated Diseases	Als, Alzheimer's Disease, Amorphous Aggregates, Amyotrophic Lateral Sclerosis, Cancer
Known Drugs/Compounds	G-Quadruplex Structured Dna, Ionic Strength, Irinotecan, Single-Stranded Dna, Viral Genome G-Quadruplex
Interactions	Actin, ALZHEIMER, ALZHEIMER'S DISEASE, AND, App, C1Q
SciDEX Target	View Target Profile (1 clinical trials)
SciDEX Hypotheses	Axonal RNA Transport Reconstitution
KG Connections	390 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HNRNPA2B1 — AlphaFold P22626 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    HNRNPA2B1["HNRNPA2B1
RNA-binding protein
Ribonucleoprotein"]
    
    %% RNA Processing & Associated Proteins
    HNRNPA1["HNRNPA1
RNA-binding protein"]
    IGF2BP1["IGF2BP1
RNA-binding protein"]
    VALOSIN["VCP/VALOSIN
Protein processing"]
    
    %% Signaling Pathways
    NOTCH1["NOTCH1
Transcription factor"]
    NotchPath["Notch Signaling
Pathway"]
    CSNK2A1["CSNK2A1
Casein kinase"]
    EpiPath["Epigenetic
Regulation"]
    
    %% Neurodegenerative Diseases
    ALS["Amyotrophic Lateral
Sclerosis (ALS)"]
    FTD["Frontotemporal
Dementia"]
    ALZ["Alzheimer's
Disease"]
    MS["Multiple
Sclerosis"]
    Dementia["Dementia
General"]
    NeuroDegeneration["Neurodegeneration
Process"]
    
    %% Inflammatory Process
    Inflammation["Neuroinflammation
Process"]
    
    %% Connections
    HNRNPA2B1 -->|"associates with"| HNRNPA1
    HNRNPA2B1 -->|"interacts with"| IGF2BP1
    HNRNPA2B1 -->|"associates with"| VALOSIN
    
    HNRNPA2B1 -->|"activates"| CSNK2A1
    HNRNPA2B1 -->|"activates"| NOTCH1
    HNRNPA2B1 -->|"activates"| NotchPath
    HNRNPA2B1 -->|"inhibits"| EpiPath
    
    HNRNPA2B1 -->|"activates"| ALS
    HNRNPA2B1 -->|"activates"| ALZ
    HNRNPA2B1 -->|"associated with"| FTD
    HNRNPA2B1 -->|"activates"| MS
    HNRNPA2B1 -->|"associated with"| Dementia
    HNRNPA2B1 -->|"activates"| NeuroDegeneration
    
    HNRNPA2B1 -->|"regulates"| Inflammation
    Inflammation -->|"contributes to"| NeuroDegeneration
    
    NotchPath -->|"promotes"| NeuroDegeneration
    CSNK2A1 -->|"phosphorylates"| HNRNPA2B1
    
    %% Styling
    style HNRNPA2B1 fill:#006494
    style HNRNPA1 fill:#4a1a6b
    style IGF2BP1 fill:#4a1a6b
    style VALOSIN fill:#4a1a6b
    style NOTCH1 fill:#4a1a6b
    style NotchPath fill:#ef5350
    style CSNK2A1 fill:#4a1a6b
    style EpiPath fill:#1b5e20
    style ALS fill:#5d4400
    style FTD fill:#5d4400
    style ALZ fill:#5d4400
    style MS fill:#5d4400
    style Dementia fill:#5d4400
    style NeuroDegeneration fill:#ef5350
    style Inflammation fill:#ef5350

Outgoing (305)

Target	Relation	Type	Str
liquid-liquid phase separation	associated_with	process	0.95
Rna Binding	involved_in	process	0.95
RNA binding	involved_in	process	0.95
Dynamic Liquid-Like Droplets	associated_with	phenotype	0.95
Rna Maturation	involved_in	process	0.95
Liquid-Liquid Phase Separation	involved_in	process	0.95
Mrna Transport	involved_in	process	0.95
GPX4	associated_with	protein	0.93
m6A methyladenosine reader	involved_in	mechanism	0.92
Protein Aggregation	contributes_to	process	0.92
dynamic liquid-like droplets	associated_with	phenotype	0.92
RNA maturation	involved_in	process	0.90
RNA binding	mediates	process	0.90
intrinsically disordered domain	associated_with	phenotype	0.90
mRNA transport	involved_in	process	0.90
Pathogenic Protein Aggregates	associated_with	phenotype	0.90
Intrinsically Disordered Low-Complexity Domain	associated_with	mechanism	0.90
G-Quadruplex Structured Dna	binds	compound	0.90
protein aggregates	implicated_in	phenotype	0.90
Nucleic Acid Metabolism	regulates	process	0.90
Membraneless Organelles	contributes_to	cell_type	0.90
Rna Recognition Domain	associated_with	protein	0.90
Multisystem Proteinopathy	causes	disease	0.90
TAU	associated_with	protein	0.90
Ferroptosis	protects_against	process	0.89
pathogenic protein aggregates	associated_with	phenotype	0.88
Amorphous Aggregates	associated_with	phenotype	0.88
GPX4	upregulates	gene	0.87
Single-Stranded Dna	binds	compound	0.85
m6A reader	involved_in	protein	0.85
Rna Stress Granule Function	regulates	process	0.85
Hspa8 Mrna Localization	regulates	process	0.85
Cancer	associated_with	disease	0.85
Tumorigenesis	involved_in	process	0.85
Mrnas In Gabaergic Neurons	regulates	biomarker	0.85
Low-Complexity Domain	interacts_with	biomarker	0.85
RNA Stress Granule	involved_in	process	0.85
membraneless organelles	contributes_to	cell_type	0.85
Cancer	implicated_in	disease	0.85
HSPA8 mRNA Dendritic Localization	regulates	process	0.85
Viral Infection	involved_in	process	0.85
circEHD2	regulates	gene	0.85
Tau Protein Toxicity	associated_with	phenotype	0.85
DNAJB6	associated_with	gene	0.80
Alzheimer's Disease	associated_with	disease	0.80
Mrna Localization	involved_in	process	0.80
Nuclear Dna Sensing	mediates	process	0.80
GABAergic dysfunction	mediates	process	0.80
Cancer progression	contributes_to	process	0.80
Tau Toxicity	associated_with	mechanism	0.80

Incoming (112)

Source	Relation	Type	Str
CBL	degrades	protein	0.92
h-8196b893	targets	hypothesis	0.90
LNK	regulates	protein	0.90
Irinotecan	interacts_with	drug	0.90
Irinotecan	interacts_with	drug	0.90
Irinotecan	binds	drug	0.90
CBL	degrades	protein	0.88
LNK	promotes	protein	0.85
CGG repeat RNA	binds	compound	0.85
Cgg Repeat Rna	binds	variant	0.85
Ph	modulates	compound	0.85
Ionic Strength	modulates	compound	0.85
Viral Genome G-Quadruplex	interacts_with	compound	0.80
Camptothecin	binds	compound	0.80
Irinotecan	modulates	drug	0.80
Irinotecan	inhibits	drug	0.75
Irinotecan	inhibits	drug	0.75
SRPK1	inhibits	gene	0.60
GPX4	disrupts	gene	0.60
GPX4	regulates	gene	0.60
GPX4	treats	gene	0.60
WTAP	therapeutic_target	gene	0.60
TBC1D24	expressed_in	gene	0.60
FUS	associated_with	gene	0.60
NUCLEOLIN	inhibits	gene	0.60
CCNF	expressed_in	gene	0.60
MAPT	associated_with	gene	0.60
MATR3	implicated_in	gene	0.60
TNFRSF11A	activates	gene	0.60
FTO	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
RNA	associated_with	gene	0.60
RNA	degrades	gene	0.60
DNAJB6	interacts_with	gene	0.60
TNFRSF11B	activates	gene	0.60
TDP-43	associated_with	gene	0.60
ATXN2	associated_with	gene	0.60
CNTN4	expressed_in	gene	0.60
PLIN4	expressed_in	gene	0.60
BID	expressed_in	gene	0.60
HNRPU	inhibits	gene	0.60
PLIN4	encodes	gene	0.60
OPTN	associated_with	gene	0.60
RANK	activates	gene	0.60
RANKL	activates	gene	0.60
GAIN	activates	gene	0.60
CSNK2A1	activates	gene	0.60
NOTCH1	activates	gene	0.60
TAU	activates	gene	0.60
YES1	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Axonal RNA Transport Reconstitution	0.695	neurodegeneration	RNA binding protein dysregulation across
hnRNPA2B1-Mediated Structural Remodeling Controls lncRNA-002	0.684	molecular neurobiology	View

Mentioning Analyses (1)

Scientific analyses that reference this entity

RNA binding protein dysregulation across ALS FTD and AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.720

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
s:** - Temporal analysis showing mitochondrial defects precede other p	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Proposed experiment from debate on TDP-43 undergoes liquid-liquid phas	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
s:** - Single-cell RNA-seq to measure editing efficiency across differ	falsification	ALS	0.400	0.50	cell_line	proposed	$150,000
ALS Progression Rate Heterogeneity — mechanism and biomarker predictor	clinical	ALS	0.400	0.50	human	proposed	$6,550,000
ALS Regional Onset and Spread: Network-Level Staging Model	clinical	ALS	0.400	0.50	human	proposed	$7,500,000
Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk Cohorts	clinical	ALS	0.400	0.50	human	proposed	$6,550,000
Axonal Transport Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Environmental Exposure Causal Attribution in ALS — Experiment Design	validation	ALS	0.400	0.50	human	proposed	$3,000,000
Frontal and Temporal Lobe Selective Vulnerability in FTD — Mechanisms	validation	Neurodegeneration	0.400	0.50	human	proposed	$3,000,000
FTLD-Tau vs FTLD-TDP In Vivo Biomarker Differentiation	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$6,550,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
SIRT6-regulated macrophage efferocytosis epigenetically controls inflammation re [PMID:36593966]	Li B, Xin Z, Gao S, Li Y, Guo S, Fu Y, X	Theranostics	2023	1
Multisystem proteinopathy: Where myopathy and motor neuron disease converge. [PMID:33145792]	Korb MK, Kimonis VE, Mozaffar T	Muscle Nerve	2021	1
The role of m6A modification in the biological functions and diseases. [PMID:33611339]	Jiang X, Liu B, Nie Z, Duan L, Xiong Q,	Signal Transduct Target Ther	2021	1
Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liv [PMID:33213490]	Senlin Zhao, Yushuai Mi, Bingjie Guan, B	Journal of hematology & oncolo	2020	1
Rare Inherited forms of Paget's Disease and Related Syndromes. [PMID:30756140]	Ralston SH, Taylor JP	Calcif Tissue Int	2019	1
A LNK-CBL-HNRPA2B1-GPX4 signaling axis mediates dopaminergic neuron vulnerabilit [PMID:41616574]	["Liu Z", "Wang R", "Shen M", "Lan X", "	Redox biology	2026	0
Human papillomavirus 16 E6 oncoprotein promotes up-regulation of RNA-binding pro [PMID:41725810]	["Cerasuolo A", "Pecchillo Cimmino T", "	Frontiers in microbiology	2026	0
Molecular recognition and induced dimerization of hnRNP A2/B1 truncations by G-q [PMID:41888191]	["Shahatibieke D", "Tang X", "Zheng X",	Scientific reports	2026	0
LncRNA 4930544M13Rik-201 regulates CACNA2D1 expression via interacting with hnRN [PMID:41864512]	Fang Z, Liu F, Tang Q, Liu Y, Peng Y, Zh	Brain research bulletin	2026	0
Comparative Binding Analysis by Computational Methods and Quartz Crystal Microba [PMID:41728844]	["Volkova O", "Serova A", "Kravtsov V",	Journal of chemical informatio	2026	0
Functional Variants of the RAD51 Gene Contribute to Susceptibility to Non-Syndro [PMID:41918261]	Guo S, Guo T, Xu Y, Chen R, Wang X	Orthodontics & craniofacial re	2026	0
Ligand-specific conformational dynamics and interaction landscapes of hnRNPA2B1 [PMID:41853685]	Zhou Z, Li Y, Yang P, Zhu R, Li J, Wu B,	Current research in structural	2026	0
Neddylation-Mediated hnRNPA2B1 Degradation Aggravates Retinal Endothelial Cell D [PMID:41773772]	Chen TR, Zhou JX, Hou YR, Zhang YN, Li C	Investigative ophthalmology &	2026	0
Mechanistic studies on HNRNPA2B1 suggest binding but not selective recognition o [PMID:41662154]	["Park R", "Demny M", "Miller L", "Pedra	RNA biology	2026	0
Network medicine modeling of the m⁶A regulatory landscape identifies a KLF6-WTAP [PMID:41787499]	Xu C, Zhou Z, Lin Y, Zhang S, Cai S, Li	Journal of translational medic	2026	0
Integrative transcriptome-wide association analyses reveal PRKCG-linked GABAergi [PMID:41507195]	["Jin Y", "Cao Y", "Ma W", "Li R", "Li Y	Nature communications	2026	0
The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatic [PMID:41725222]	["Xu W", "Shi L", "Lu A", "Cui L", "Qian	Immunity, inflammation and dis	2026	0
Expression, purification, and biophysical characterization of liquid-liquid phas [PMID:41297573]	["Dur\u00e1n-Armenta L", "Meszaros A", "	Protein expression and purific	2026	0
Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progre [PMID:34453888]	Jiang L, Lin W, Zhang C, Ash PEA, Verma	Molecular cell	2021	0
Stress granule mediated protein aggregation and underlying gene defects in the F [PMID:31626953]	Baradaran-Heravi Y, Van Broeckhoven C, v	Neurobiology of disease	2020	0

Debates (2)

Multi-agent debates referencing this entity

RNA binding protein dysregulation across ALS FTD and AD

closed · Rounds: 4 · Score: 0.72 · 2026-04-12

RNA binding protein dysregulation across ALS FTD and AD

closed · Rounds: 4 · Score: 0.88 · 2026-04-06

Related Research

Hypotheses and analyses mentioning HNRNPA2B1 in their description or question text

No additional research found

HNRNPA2B1

Understanding Entity Pages

Summary

Wiki Pages (5)

HNRNPA2B1 Protein

HNRNPA2B1 - Heterogeneous Nuclear Ribonucleoprotein A2/B1

Heterogeneous Nuclear Ribonucleoprotein A2/B1 (HNRNPA2B1)

HNRNPA2B1 Gene

HNRNPA2B1 Protein

Pathway Diagram

Outgoing (305)

Incoming (112)

Targeting Hypotheses (2)

Mentioning Analyses (1)

RNA binding protein dysregulation across ALS FTD and AD

Experiments (10)

Related Papers (20)

Debates (2)

RNA binding protein dysregulation across ALS FTD and AD

RNA binding protein dysregulation across ALS FTD and AD

Related Research