concept

CANCER PROGRESSION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CANCER PROGRESSION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

42Connections

1Hypotheses

0Analyses

0Outgoing

42Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CANCER PROGRESSION

Pathway Diagram

graph TD
    CANCER_PROGRESSION["CANCER PROGRESSION"]
    LOX["LOX"] -->|"involved_in"| CANCER_PROGRESSION
    LOXL1["LOXL1"] -->|"involved_in"| CANCER_PROGRESSION
    LOXL2["LOXL2"] -->|"involved_in"| CANCER_PROGRESSION
    LOXL3["LOXL3"] -->|"involved_in"| CANCER_PROGRESSION
    LOXL4["LOXL4"] -->|"involved_in"| CANCER_PROGRESSION
    Complement_System["Complement System"] -->|"modulates"| CANCER_PROGRESSION
    MYC["MYC"] -->|"promotes"| CANCER_PROGRESSION
    EGFR_mutations["EGFR mutations"] -->|"causes"| CANCER_PROGRESSION

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (42)

Source	Relation	Type	Str
LOX	involved_in	gene	0.95
LOXL3	involved_in	gene	0.95
LOXL1	involved_in	gene	0.95
ECM	promotes	process	0.95
LOXL4	promotes	gene	0.95
Complement System	modulates	pathway	0.95
LOX	promotes	gene	0.95
LOXL2	involved_in	gene	0.95
MYC	promotes	gene	0.95
LOXL1	promotes	gene	0.95
LOXL2	promotes	gene	0.95
LOXL3	promotes	gene	0.95
Stress Granules	associated_with	process	0.95
LOXL4	involved_in	gene	0.95
EGFR overexpression	causes	gene	0.90
Ferroptosis	associated_with	process	0.90
EGFR mutations	causes	gene	0.90
Cancer Cell Plasticity	promotes	process	0.90
Cancer Cell Plasticity	contributes_to	process	0.90
N6-Methyladenosine	mediates	compound	0.90
PI3K/Akt/mTOR Pathway	regulates	pathway	0.90
m6A modification	drives	process	0.90
PSME2	associated_with	gene	0.88
Metabolic Reprogramming	contributes_to	process	0.88
Efnb1-Ephb4	promotes	protein	0.85
Senescence	contributes_to	process	0.85
Intratumor Heterogeneity	associated_with	phenotype	0.85
m6A Modification	involved_in	process	0.85
Irinotecan	suppresses	drug	0.85
Netrin-1 Inhibition	inhibits	mechanism	0.85
Ecm Stiffness-Induced Oncogenic Signaling	mediates	mechanism	0.85
TFR1	promotes	protein	0.85
CD274	promotes	protein	0.80
Hnrnpa2B1	contributes_to	protein	0.80
Neuronal Targets	involved_in	biomarker	0.80
Fatty Liver Disease	risk_factor_for	disease	0.80
Liver Metabolic Dysfunction	contributes_to	phenotype	0.80
NTN1	promotes	protein	0.80
NF-κB	promotes	pathway	0.75
autophagy	regulates	process	0.70
MAMs	contributes_to	process	0.70
Senescence	promotes	biological_process	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Epigenetic Silencing of Tumor Suppressor Genes in Cancer Pro	0.438	-	-

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CANCER PROGRESSION in their description or question text

No additional research found