gene

YES1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about YES1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections

0Hypotheses

0Analyses

25Outgoing

3Incoming

0Experiments

0Debates

Summary

Page for YES1 — YES Proto-Oncogene 1, Src Family Tyrosine Kinase

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🧬 Gene Info

Gene Symbol	YES1
Full Name	YES Proto-Oncogene 1, Src Family Tyrosine Kinase
Chromosome	18p11.32
Protein Type	Receptor
Function	Synaptic Plasticity: YES1 is enriched in synaptic fractions and regulates AMPA and NMDA receptor trafficking [4].
Primary Expression	various tissues including the brain, where it participates in signaling pathways controlling cell proliferation, differentiation, and survival
Molecular Weight	60 kDa
Amino Acids	536 aa
UniProt ID	https://www.uniprot.org/uniprot/P42681 P42681
Ensembl ID	ENSG00000106105
GeneCards	YES1
Human Protein Atlas	YES1
Associated Diseases	neurodegeneration
Interactions	AND, CANCER, CYTOKINES, FUS, HNRNPA2B1, IL-6
KG Connections	28 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

YES1 — YES Proto-Oncogene 1, Src Family Tyrosine Kinase

gene · 684 words

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Pathway Diagram

graph TD
    YES1["YES1"]
    Als{"Als"}
    YES1 -->|"therapeutic target"| Als
    Cancer{"Cancer"}
    YES1 -->|"therapeutic target"| Cancer
    Tumor{"Tumor"}
    YES1 -->|"therapeutic target"| Tumor
    CANCER["CANCER"]
    YES1 -->|"therapeutic target"| CANCER
    Mapk(["Mapk"])
    YES1 -->|"therapeutic target"| Mapk
    neurodegeneration["neurodegeneration"]
    YES1 -->|"implicated in"| neurodegeneration
    FYN["FYN"]
    FYN -->|"expressed in"| YES1
    ERK["ERK"]
    ERK -->|"therapeutic target"| YES1
    SRC["SRC"]
    SRC -->|"expressed in"| YES1
    style YES1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (25)

Target	Relation	Type	Str
Obesity	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
YAP	activates	gene	0.60
IL-6	activates	gene	0.60
CYTOKINES	activates	gene	0.60
ATF1	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
Mapk	therapeutic_target	pathway	0.60
SRC	associated_with	gene	0.60
CANCER	activates	gene	0.60
SOX9	activates	gene	0.60
HNRNPA2B1	activates	gene	0.60
YWHAH	activates	gene	0.60
FUS	activates	gene	0.60
AND	activates	gene	0.60
YAP	associated_with	gene	0.60
CREB	therapeutic_target	gene	0.60
KRAS	associated_with	gene	0.60

Incoming (3)

Source	Relation	Type	Str
FYN	expressed_in	gene	0.60
SRC	expressed_in	gene	0.60
ERK	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning YES1 in their description or question text

No additional research found