concept

LIQUID-LIQUID PHASE SEPARATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LIQUID-LIQUID PHASE SEPARATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections

7Hypotheses

6Analyses

18Outgoing

22Incoming

3Experiments

9Debates

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💡 Concept Info

Name	LIQUID-LIQUID PHASE SEPARATION

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Liquid-Liquid Phase Separation

mechanism · 2761 words

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Pathway Diagram

graph TD
    LIQUID_LIQUID_PHASE_SEPARATION["LIQUID-LIQUID PHASE SEPARATION"]
    LIQUID_LIQUID_PHASE_SEPARATION -->|"involved_in"| Stress_Granules["Stress Granules"]
    LIQUID_LIQUID_PHASE_SEPARATION -->|"mediates"| Biomolecular_Condensates["Biomolecular Condensates"]
    LIQUID_LIQUID_PHASE_SEPARATION -->|"regulates"| Alpha_Synuclein_Aggregate["Alpha-Synuclein Aggregate"]
    LIQUID_LIQUID_PHASE_SEPARATION -->|"involved_in"| Pulmonary_Hypertension["Pulmonary Hypertension"]
    LIQUID_LIQUID_PHASE_SEPARATION -->|"regulates"| Mitophagy["Mitophagy"]
    G3BP1["G3BP1"] -->|"mediates"| LIQUID_LIQUID_PHASE_SEPARATION
    Alpha_Synuclein["Alpha-Synuclein"] -->|"involved_in"| LIQUID_LIQUID_PHASE_SEPARATION
    Stress_Granules -->|"involved_in"| LIQUID_LIQUID_PHASE_SEPARATION
    TRIAD3A["TRIAD3A"] -->|"mediates"| LIQUID_LIQUID_PHASE_SEPARATION
    TDP_43_Oligomerization["TDP-43 Oligomerization"] -->|"involved_in"| LIQUID_LIQUID_PHASE_SEPARATION
    G3BP1_Ubiquitination["G3BP1 Ubiquitination"] -->|"inhibits"| LIQUID_LIQUID_PHASE_SEPARATION

Outgoing (18)

Target	Relation	Type	Str
Stress Granules	involved_in	process	0.95
stress granules	drives	process	0.95
condensate formation	mediates	process	0.95
Nanocondensates	associated_with	mechanism	0.95
Biomolecular Condensates	mediates	process	0.95
Stress Granules	mediates	process	0.90
Stress Granules	promotes	process	0.90
Alpha-Synuclein Aggregate	regulates	mechanism	0.90
Pathogenic Protein Aggregates	associated_with	phenotype	0.90
protein aggregates	associated_with	phenotype	0.85
Pulmonary Hypertension	involved_in	disease	0.85
Mitophagy	regulates	process	0.85
Nuclear TDP-43 Aggregation	mediates	phenotype	0.80
protein aggregates	regulates	phenotype	0.80
Cell Cycle Regulation	involved_in	process	0.80
Pulmonary Hypertension	contributes_to	disease	0.80
Cell-Cycle Regulation	involved_in	process	0.75
tau condensation	associated_with	process	0.50

Incoming (22)

Source	Relation	Type	Str
Hnrnpa2B1	associated_with	protein	0.95
Tardbp	involved_in	protein	0.95
Alpha-Synuclein	involved_in	protein	0.95
TDP43	associated_with	protein	0.95
G3BP1	mediates	protein	0.95
Stress Granules	involved_in	process	0.95
HNRNPA2B1	involved_in	protein	0.95
G3BP1	mediates	entity	0.95
TRIAD3A	mediates	protein	0.93
FUS	regulates	gene	0.90
G3BP1	involved_in	protein	0.90
TARDBP	involved_in	protein	0.90
G3BP1	regulates	protein	0.90
Tardbp	mediates	protein	0.90
TDP-43 Oligomerization	involved_in	process	0.88
Phosphorylation	regulates	process	0.85
Chemical Modulators Of Phase Separation	modulates	compound	0.85
G3BP1 Ubiquitination	inhibits	process	0.85
G3BP1 missense mutations	activates	gene	0.70
TDP-43	associated_with	protein	0.70
YTHDC1	undergoes	protein	0.70
TRIM21	modulates	protein	0.70

Targeting Hypotheses (7)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
RBM45 Liquid-Liquid Phase Separation Dominance Hijacks RNA P	0.868	ALS	View
HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43	0.820	neurodegeneration	What is the therapeutic window between i
LAMP2A Liquid-Liquid Phase Separation Defects in Dopaminergi	0.783	neurodegeneration	View
TDP-43 Liquid-Liquid Phase Separation Dominance in Stress Gr	0.650	Alzheimer's disease	-
p62 Liquid-Liquid Phase Separation Nucleates Cross-Organelle	0.649	neurodegeneration	How do different organelle-specific auto

Liquid-Liquid Phase Separation Modifier Therapy	0.551	neurodegeneration	Protein aggregation cross-seeding across
Liquid-Liquid Phase Separation (LLPS) Saturation Partitionin	0.461	neurodegeneration	What determines the spatial organization

Mentioning Analyses (6)

Scientific analyses that reference this entity

How does FUS loss-of-function in TAZ regulation contribute to ALS/FTD pathogenes

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.720

What is the atomic-resolution structure of K280-acetylated tau and how does it t

structural biology | 2026-04-13 | 1 hypotheses Top: 0.643

What determines the specificity of RNA-protein interactions that drive distinct

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.712

How does TRIM21-mediated K63 ubiquitination of G3BP1 mechanistically inhibit liq

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.730

How do disease-associated mutations in G3BP1 or its binding partners alter stres

neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.700

Experiments (3)

Experimental studies targeting or related to this entity

Experiment	Type	Score	Model	Status	Est. Cost
G3BP1-mediated stress granule assembly via liquid-liquid phase separat	exploratory	0.900	eukaryotic cells	proposed	N/A
G3BP1 intrinsically disordered region analysis and phosphorylation eff	exploratory	0.850	in vitro protein analysis syst	proposed	N/A
G3BP1-binding factor cooperativity in stress granule network regulatio	exploratory	0.800	cell culture systems with prot	proposed	N/A

Related Papers (11)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Pharmacological modulation of stress granules via G3BP1/2: A pathway to treat ca [PMID:41924133]	Yang J, Gao F	Front Pharmacol	2026
Stress granules at the crossroads of retroviral replication and antiviral immuni [PMID:41931190]	Akbarin MM, Farjami Z, Álvarez HR	Mol Biol Rep	2026
Pharmacological modulation of stress granules via G3BP1/2: A pathway to treat ca [PMID:41924133]	Yang J, Gao F	Frontiers in pharmacology	2026
Disruption of G3BP1 granules promotes mammalian CNS and PNS axon regeneration. [PMID:40014573]	["Sahoo P", "Agrawal M", "Hanovice N", "	Proceedings of the National Ac	2025
β-propeller protein-associated neurodegeneration protein WDR45 regulates stress [PMID:40473629]	["Li Y", "Fang J", "Ding Y", "Zhang X",	Nature communications	2025
Identification of small molecule inhibitors of G3BP-driven stress granule format [PMID:38284934]	["Freibaum B", "Messing J", "Nakamura H"	The Journal of cell biology	2024
Stress granule formation helps to mitigate neurodegeneration. [PMID:39106168]	Glineburg MR, Yildirim E, Gomez N, Rodri	Nucleic acids research	2024
[WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268]	Wieschollek S, Forster S, Megerle K	Handchirurgie, Mikrochirurgie,	2022
Future rice farming threatened by drought in the Lower Mekong Basin. [PMID:33931657]	Kang H, Sridhar V, Mainuddin M, Trung LD	Scientific reports	2021
Engineering complex communities by directed evolution. [PMID:33986540]	Chang CY, Vila JCC, Bender M, Li R, Mank	Nature ecology & evolution	2021
Sex differences in myelin content of white matter tracts in adolescents with dep [PMID:34215842]	Ho TC, Sisk LM, Kulla A, Teresi GI, Hans	Neuropsychopharmacology : offi	2021