concept

PROTEIN AGGREGATES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PROTEIN AGGREGATES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections

2Hypotheses

2Analyses

16Outgoing

44Incoming

0Experiments

2Debates

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💡 Concept Info

Name	PROTEIN AGGREGATES
Related Diseases	Neurodegeneration

Pathway Diagram

graph TD
    PROTEIN_AGGREGATES["PROTEIN AGGREGATES"]
    PROTEIN_AGGREGATES -->|"contributes to"| Myofibrillar_Degeneration["Myofibrillar Degeneration"]
    PROTEIN_AGGREGATES -->|"involved_in"| Tunnelling_Nanotubes["Tunnelling Nanotubes"]
    PROTEIN_AGGREGATES -->|"causes"| Neurodegeneration["Neurodegeneration"]
    PROTEIN_AGGREGATES -->|"causes"| neurodegenerative_disorders["neurodegenerative disorders"]
    PROTEIN_AGGREGATES -->|"activates"| Neuroinflammation["Neuroinflammation"]
    Autophagy["Autophagy"] -->|"degrades"| PROTEIN_AGGREGATES
    Aggrephagy["Aggrephagy"] -->|"involved_in"| PROTEIN_AGGREGATES
    AUTOPHAGY_RECEPTORS["AUTOPHAGY RECEPTORS"] -->|"targets"| PROTEIN_AGGREGATES
    CCDC50["CCDC50"] -->|"targets"| PROTEIN_AGGREGATES
    TRIM22["TRIM22"] -->|"involved_in"| PROTEIN_AGGREGATES
    EMP1["EMP1"] -->|"suppresses"| PROTEIN_AGGREGATES
    autophagy["autophagy"] -->|"regulates"| PROTEIN_AGGREGATES

Outgoing (16)

Target	Relation	Type	Str
Myofibrillar Degeneration	contributes_to	phenotype	0.90
Neurodegeneration	contributes_to	disease	0.90
NEUROINFLAMMATION	causes	process	0.90
Tunnelling Nanotubes	involved_in	process	0.88
NEURON	causes	cell_type	0.85
Neurodegeneration	biomarker_for	process	0.85
Endoplasmic Reticulum Stress	causes	process	0.85
Neurodegeneration	causes	disease	0.85
Cellular Cytotoxicity	causes	process	0.85
neuroinflammation	induces	process	0.80
nucleocytoplasmic transport	inhibits	process	0.80
Neuroinflammation	activates	process	0.70
neurodegenerative diseases	causes	disease	0.70
cellular components	interacts_with	cell_type	0.70
neurodegeneration	biomarker_for	disease	0.70
neurodegenerative disorders	causes	disease	0.70

Incoming (44)

Source	Relation	Type	Str
CCDC50	mediates	gene	0.95
SQSTM1	binds	protein	0.95
Autophagy	mediates	process	0.95
Aggrephagy	involved_in	process	0.95
Autophagy	degrades	process	0.95
ATG2A-G433A	causes	variant	0.93
Microglia	degrades	cell_type	0.90
NEUROINFLAMMATION	promotes	process	0.90
Autophagy	involved_in	process	0.90
CCDC50	mediates	gene	0.90
AUTOPHAGY RECEPTORS	targets	protein	0.90
autophagy	degrades	process	0.90
Hnrnpa2B1	implicated_in	protein	0.90
Tdp-43	contributes_to	protein	0.90
35517053	may disassemble and/or degrade	paper	0.90
35517053	disassemble and/or degrade	paper	0.90
CCDC50	targets	protein	0.90
AUTOPHAGY	degrades	pathway	0.90
Ubiquitin-Proteasome System	degrades	pathway	0.90
EMP1	suppresses	protein	0.85
Ubiquitin	involved_in	protein	0.85
TRIM22	involved_in	protein	0.85
liquid-liquid phase separation	associated_with	process	0.85
proCTSD	targets	drug	0.85
HDAC6	degrades	protein	0.85
liquid-liquid phase separation	regulates	process	0.80
MICROGLIA	clears	cell_type	0.80
MICROGLIA	propagates	cell_type	0.80
TDP-43	aggregates_with	protein	0.80
autophagy-lysosomal pathway	inhibits	pathway	0.70
NBR1	recognizes	protein	0.70
aggrephagy	activates	process	0.70
P62	recognizes	protein	0.70
TRIM22	regulates	protein	0.70
APOE4	causes	gene	0.70
autophagy	regulates	process	0.70
autophagy	activates	process	0.70
tau	causes	protein	0.70
ATG	regulates	pathway	0.70
CTSD	disrupts	gene	0.70
autophagy	protects_against	pathway	0.70
α-synuclein	causes	protein	0.70
amyloid-β	causes	protein	0.70
TRIM22	activates	protein	0.70

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TFEB-mediated Autophagy Enhancement to Clear Protein Aggrega	0.380	proteomics	Quantitative proteomics of the aging syn
J-protein co-chaperone system mediates selective autophagy t	0.000	protein biochemistry	Do chaperones selectively recognize path