gene

ABCG2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ABCG2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

239Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ABCG2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with Als, Alzheimer, Anxiety. Connected to 152 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ABCG2
Full Name	ATP Binding Cassette Subfamily G Member 2
Chromosome	4q22.1
Protein Type	Transporter
Function	encodes a 72 kDa half-transporter that functions as a homodimer at the blood-brain barrier.
Molecular Weight	72 kDa
Exons	16
Pathways	Akt, Apoptosis, Autophagy, Blood-Brain Barrier, Cell Cycle
Ensembl ID	ENSG00000118777
GeneCards	ABCG2
Human Protein Atlas	ABCG2
Homodimeric architecture	Two ABCG2 monomers assemble via extensive TMD interactions to form a functional transporter with a central drug-binding cavity
Substrate specificity	Preferentially transports sulfated and glucuronidated conjugates, porphyrins, dietary flavonoids, urate, and various chemotherapeutic agents
Cooperative transport	Some substrates show positive cooperativity, with binding at one site enhancing transport at the other
Associated Diseases	Alzheimer, Alzheimer's disease, Anxiety, Dementia, Depression
Interactions	ABCB1, AKT, AMPK, AND, ATP, AUTOPHAGY
KG Connections	239 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member 2

gene · 1180 words

→

ABCG2 Protein

protein · 1054 words

→

Pathway Diagram

graph TD
    ABCG2["ABCG2"] -->|"associated"| Alzheimer["Alzheimer"]
    ABCG2["ABCG2"] -->|"therapeutic target"| Dementia["Dementia"]
    ABCG2["ABCG2"] -->|"associated"| Depression["Depression"]
    ABCG2["ABCG2"] -->|"associated"| Anxiety["Anxiety"]
    ABCG2["ABCG2"] -->|"regulates"| Inflammation["Inflammation"]
    ABCG2["ABCG2"] -->|"therapeutic target"| Ms["Ms"]
    MAOB["MAOB"] -->|"associated"| ABCG2["ABCG2"]
    GABRA1["GABRA1"] -->|"associated"| ABCG2["ABCG2"]
    CHAT["CHAT"] -->|"associated"| ABCG2["ABCG2"]
    CYP2D6["CYP2D6"] -->|"associated"| ABCG2["ABCG2"]
    style ABCG2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (164)

Target	Relation	Type	Str
R-HSA-9725554	member_of	pathway	1.00
R-HSA-189483	member_of	pathway	1.00
R-HSA-2161517	member_of	pathway	1.00
R-HSA-917937	member_of	pathway	1.00
R-HSA-1660661	member_of	pathway	1.00
R-HSA-9753281	member_of	pathway	1.00
R-HSA-9793528	member_of	pathway	1.00
R-HSA-9818032	member_of	pathway	1.00
R-HSA-189451	member_of	pathway	1.00
Cancer	therapeutic_target	disease	0.75
Tumor	therapeutic_target	disease	0.75
Cancer	activates	disease	0.65
Ms	activates	disease	0.65
Diabetes	activates	disease	0.65
Dementia	associated_with	disease	0.65
Dementia	interacts_with	disease	0.65
Tumor	inhibits	disease	0.65
Carcinoma	expressed_in	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Depression	associated_with	disease	0.65
Anxiety	associated_with	disease	0.65
Breast Cancer	therapeutic_target	disease	0.65
Cancer	expressed_in	disease	0.65
Fibrosis	inhibits	disease	0.65
Inflammation	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
Glioblastoma	inhibits	disease	0.65
Als	activates	disease	0.65
Inflammation	inhibits	disease	0.65
Tumor	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
Leukemia	expressed_in	disease	0.65
Cancer	regulates	disease	0.65
Als	regulates	disease	0.65
NOS2	activates	gene	0.60
SLC2A1	activates	gene	0.60
BCL-2	activates	gene	0.60
HO-1	activates	gene	0.60
Tgf-Β	inhibits	pathway	0.60
OCLN	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Apoptosis	associated_with	pathway	0.60
Blood-Brain Barrier	therapeutic_target	pathway	0.60
Apoptosis	inhibits	pathway	0.60

Incoming (75)

Source	Relation	Type	Str
genes-abcg2	describes	wiki_page	0.95
AMPK	activates	gene	0.70
PER	therapeutic_target	gene	0.60
ABCB1	associated_with	gene	0.60
PI3K	therapeutic_target	gene	0.60
BID	therapeutic_target	gene	0.60
NRF2	therapeutic_target	gene	0.60
JNK	therapeutic_target	gene	0.60
STAT3	inhibits	gene	0.60
SMAD3	inhibits	gene	0.60
JAK2	inhibits	gene	0.60
CYP3A5	associated_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
JAK	therapeutic_target	gene	0.60
DEPRESSION	associated_with	gene	0.60
PER	interacts_with	gene	0.60
CYP2E1	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
ANXIETY	associated_with	gene	0.60
GENES	interacts_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
BCL-2	activates	gene	0.60
BAX	activates	gene	0.60
RAB7A	inhibits	gene	0.60
MFN2	activates	gene	0.60
GSDMD	activates	gene	0.60
CAT	activates	gene	0.60
ABCB1	interacts_with	gene	0.60
ABCB1	activates	gene	0.60
ABCB1	therapeutic_target	gene	0.60
ABCB1	expressed_in	gene	0.60
ABCB1	regulates	gene	0.60
CD44	therapeutic_target	gene	0.60
STAT3	therapeutic_target	gene	0.60
AKT	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
CANCER	expressed_in	gene	0.60
CANCER	therapeutic_target	gene	0.60
CANCER	regulates	gene	0.60
GABRA1	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
CYP2D6	associated_with	gene	0.60
APOE	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
COMT	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ABCG2 in their description or question text

No additional research found