concept

MICROTUBULES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MICROTUBULES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

435Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MICROTUBULES is a concept in neurodegeneration research. Key relationships include: activates, interacts with, regulates. Associated with ALS, Aging, Als. Connected to 162 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	MICROTUBULES
Key Genes/Proteins	ABCB1, Actin, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMBRA1
Related Diseases	Aging, Als, ALS, Alzheimer, Alzheimer'S Disease
Related Pathways	Amyloid

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Expand Microtubules content

entity · 1565 words

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Pathway Diagram

graph TD
    MICROTUBULES["MICROTUBULES"]
    MICROTUBULES -->|"inhibits"| Ischemia["Ischemia"]
    MICROTUBULES -->|"inhibits"| Ms["Ms"]
    MICROTUBULES -->|"inhibits"| Tumor["Tumor"]
    MICROTUBULES -->|"activates"| Cancer["Cancer"]
    MICROTUBULES -->|"expressed in"| Aging["Aging"]
    MICROTUBULES -->|"expressed in"| Cardiac["Cardiac"]
    MICROTUBULES -->|"interacts"| Neurodegeneration["Neurodegeneration"]
    OPTN["OPTN"] -->|"binds"| MICROTUBULES
    KINESIN_1["KINESIN-1"] -->|"transports"| MICROTUBULES
    REEP1["REEP1"] -->|"stabilizes"| MICROTUBULES
    RAB7["RAB7"] -->|"activates"| MICROTUBULES
    MTOR["MTOR"] -->|"interacts"| MICROTUBULES
    ENDOSOMES["ENDOSOMES"] -->|"interacts"| MICROTUBULES
    BCL2["BCL2"] -->|"inhibits"| MICROTUBULES
    TLR4["TLR4"] -->|"inhibits"| MICROTUBULES
    MYD88["MYD88"] -->|"inhibits"| MICROTUBULES
    TNF["TNF"] -->|"inhibits"| MICROTUBULES

Outgoing (266)

Target	Relation	Type	Str
Axon Development	involved_in	process	0.95
Dendrite Development	involved_in	process	0.95
Organelle Transport	involved_in	process	0.95
Organelle Transport	mediates	process	0.90
Cytoskeleton	associated_with	pathway	0.85
Neurite Extension	involved_in	process	0.85
Golgi Complex	associated_with	cell_type	0.85
ALS	activates	disease	0.75
Aging	interacts_with	disease	0.65
Alzheimer	causes	disease	0.65
Huntington	causes	disease	0.65
Cancer	interacts_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Schizophrenia	expressed_in	disease	0.65
ALS	interacts_with	disease	0.65
Alzheimer	activates	disease	0.65
Inflammation	causes	disease	0.65
Inflammation	activates	disease	0.65
Als	expressed_in	disease	0.65
Ms	causes	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Alzheimer	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Hypertension	activates	disease	0.65
ALS	causes	disease	0.65
Als	activates	disease	0.65
Infection	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Parkinson	causes	disease	0.65
Glaucoma	activates	disease	0.65
Dementia	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Amyotrophic Lateral Sclerosis	causes	disease	0.65
Als	regulates	disease	0.65
Tumor	regulates	disease	0.65
Frontotemporal Dementia	activates	disease	0.65
Als	interacts_with	disease	0.65
ALS	associated_with	disease	0.65
Ms	activates	disease	0.65
Als	transports	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Tumor	therapeutic_target	disease	0.65
Neurodegeneration	causes	disease	0.65
Als	causes	disease	0.65

Incoming (169)

Source	Relation	Type	Str
TAU	associated_with	protein	0.95
MAPT	interacts_with	protein	0.95
OPTN	interacts_with	protein	0.90
Tau	interacts_with	protein	0.90
OPTN	binds	gene	0.90
TAU	binds	gene	0.90
MAP6	associated_with	protein	0.90
MAPT	regulates	protein	0.90
Tau	binds	protein	0.90
MAP6	interacts_with	protein	0.90
MAPT	component_of	protein	0.90
PAFAH1B1	interacts_with	protein	0.85
DCX	interacts_with	protein	0.85
TAU	interacts_with	protein	0.85
MAPT	associated_with	gene	0.80
REEP1	stabilizes	gene	0.80
Actin Filaments	interacts_with	protein	0.75
AXONAL MITOCHONDRIAL TRANSPORT	interacts_with	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
DEMENTIA	activates	gene	0.60
AND	expressed_in	gene	0.60
INFLAMMATION	activates	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
JUN	associated_with	gene	0.60
VCP	causes	gene	0.60
AUTOPHAGY	causes	gene	0.60
ALZHEIMER	associated_with	gene	0.60
UBIQUITIN	causes	gene	0.60
HSP70	causes	gene	0.60
TAU	associated_with	gene	0.60
CANCER	therapeutic_target	gene	0.60
AND	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
OPTINEURIN	activates	gene	0.60
ALS	activates	gene	0.60
AQP4	regulates	gene	0.60
MFN2	regulates	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
NEURON	associated_with	gene	0.60
CDK5	causes	gene	0.60
AXON	causes	gene	0.60
LIS1	interacts_with	gene	0.60
NEURON	causes	gene	0.60
DCX	causes	gene	0.60
DYNEIN	interacts_with	gene	0.60
AMYLOID	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
APOPTOSIS	regulates	gene	0.60
MAP2	contributes_to	gene	0.60
MAP6	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MICROTUBULES in their description or question text

No additional research found