gene

REEP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about REEP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4Connections

0Hypotheses

0Analyses

4Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for REEP1 Gene

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🧬 Gene Info

Gene Symbol	REEP1
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	22 kDa
Amino Acids	199 aa
Pathways	PI3K/Akt pathway
Ensembl ID	ENSG00000068615
GeneCards	REEP1
Human Protein Atlas	REEP1
Mitochondrial Cristae Structure	Shapes mitochondrial cristae and maintains cristae junctions essential for optimal oxidative phosphorylation
Axonal Mitochondria Distribution	Critical for proper distribution and anchoring of mitochondria in axons, particularly at synaptic terminals
ER-Mitochondria Contacts	Regulates membrane contact sites (MCS) between endoplasmic reticulum and mitochondria for calcium exchange and lipid transfer
Axonal Transport	Works with microtubule motors (kinesin/dynein) for organelle trafficking along axons
Mitochondrial Protein Import	Facilitates import of proteins into the mitochondrial matrix
Brain	Cerebral cortex, hippocampus, basal ganglia, and Purkinje cells of cerebellum
Spinal Cord	Motor neurons in the ventral horn
Associated Diseases	muscular_dystrophy, white_matter_damage
KG Connections	4 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

REEP1 Gene

gene · 620 words

→

REEP1 Protein

protein · 789 words

→

Pathway Diagram

graph TD
    REEP1["REEP1"]
    microtubules["microtubules"]
    REEP1 -->|"stabilizes"| microtubules
    apoptosis["apoptosis"]
    REEP1 -->|"inhibits"| apoptosis
    PI3K_Akt_pathway(["PI3K/Akt pathway"])
    REEP1 -->|"regulates"| PI3K_Akt_pathway
    white_matter_damage{"white_matter_damage"}
    REEP1 -->|"associated with"| white_matter_damage
    muscular_dystrophy{"muscular_dystrophy"}
    REEP1 -->|"associated with"| muscular_dystrophy
    neurodegeneration["neurodegeneration"]
    REEP1 -->|"implicated in"| neurodegeneration
    style REEP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (4)

Target	Relation	Type	Str
microtubules	stabilizes	biological_process	0.80
PI3K/Akt pathway	regulates	pathway	0.80
white_matter_damage	associated_with	disease	0.70
muscular_dystrophy	associated_with	disease	0.70

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning REEP1 in their description or question text

No additional research found