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protein 654 words KG: VAMP2
Contents

VAMP2 Protein

🔬 Protein Info
Gene SymbolVAMP2
AliasesPage for VAMP2 Gene, Synaptobrevin-2
Chromosome17p13.1
Protein TypeProtein
FunctionVesicle Docking: VAMP2 on vesicles pairs with syntaxin-1A on plasma membrane
Molecular Weight12.6 kDa
Amino Acids116 aa
Exons5
UniProt IDP60880
GeneCardsVAMP2
Human Protein AtlasVAMP2
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsAGING, ALPHA-SYNUCLEIN, AMYLOID, AND, APOE, APOE3
KG Connections77 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (17)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74

Related Analyses (11)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedSEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (1)

Synaptic Vesicle Trafficking Dysfunction Validation in Parki
clinical · proposed · Score: 0.40

See Also (10)

SNAP-25
biomarker · KG edge: co_discussedNeuRon Therapeutics
company · KG edge: inhibitsNeurodegeneration
disease · KG edge: interacts_withAmyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: interacts_withBDNF Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

APOE4 interacts_with VAMP2
APOE interacts_with VAMP2
SNAP25 co_discussed VAMP2
TAU co_discussed VAMP2
STX1A expressed_in VAMP2
NLRP3 expressed_in VAMP2
BDNF expressed_in VAMP2
VAMP2 expressed_in PSD95
VAMP2 expressed_in BAX
VAMP2 expressed_in SNAP25

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