protein

SYNTAXIN-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNTAXIN-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

1Hypotheses

0Analyses

2Outgoing

4Incoming

0Experiments

0Debates

Summary

STX1 — Syntaxin-1

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🔬 Protein Info

Gene Symbol	SYNTAXIN
Full Name	STX1 — Syntaxin-1
Aliases	Syntaxin-1
Protein Type	Protein
Function	is a presynaptic plasma-membrane SNARE protein essential for fast calcium-triggered neurotransmitter release
UniProt ID	Search UniProt
GeneCards	SYNTAXIN
Human Protein Atlas	SYNTAXIN
Associated Diseases	Neurodegeneration-Relevant Mechanisms
Interactions	PSD-95, SNAP-25, SNARE, VAMP2
KG Connections	6 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SYNTAXIN-1 — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

flowchart TD
    SYNTAXIN_1(["SYNTAXIN-1"])
    Cortex["Cortex"]
    CEREBRAL_CORTEX("CEREBRAL CORTEX")
    VAMP2(["VAMP2"])
    SNARE(["SNARE"])
    SNAP_25(["SNAP-25"])
    PSD_95(["PSD-95"])

    SYNTAXIN_1 -->|"activates"| Cortex
    SYNTAXIN_1 -->|"activates"| CEREBRAL_CORTEX
    VAMP2 -->|"activates"| SYNTAXIN_1
    SNARE -->|"activates"| SYNTAXIN_1
    SNAP_25 -->|"activates"| SYNTAXIN_1
    PSD_95 -->|"activates"| SYNTAXIN_1

    style SYNTAXIN_1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (2)

Target	Relation	Type	Str
Cortex	activates	brain_region	0.50
CEREBRAL CORTEX	activates	concept	0.50

Incoming (4)

Source	Relation	Type	Str
VAMP2	activates	gene	0.50
SNARE	activates	protein	0.50
SNAP-25	activates	protein	0.50
PSD-95	activates	protein	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Cytosolic TDP-43 aggregation sequesters SNAP29 and syntaxin-	0.600	neurodegeneration	What are the neuron-specific effects of

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SYNTAXIN-1 in their description or question text

No additional research found