gene 2,470 words KG: SYNJ1
Contents

SYNJ1 — Synaptojanin 1

🧬 Gene Info
Gene SymbolSYNJ1
Full NameSynaptojanin 1
Chromosome21q22.11
Protein TypePhosphatase
FunctionSYNJ1 is crucial for synaptic vesicle cycling
Molecular Weight165 kDa
Amino Acids428 aa
Exons31
PathwaysEndosomal Sorting
UniProt IDSYNJ1
GeneCardsSYNJ1
Human Protein AtlasSYNJ1
Associated DiseasesAls, Cancer, Ms, Parkinson
InteractionsAD, ATP13A2, BIN1, DJ1, DNAJC6, FBXO7
KG Connections119 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (3)

APOE-Dependent Autophagy Restoration
Score: 0.85
Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
Score: 0.47
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67

Related Analyses (3)

Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Parkinson Basal Ganglia Circuit
circuit · KG edge: associated_with
NeuRon Therapeutics
company · KG edge: associated_with
Astrocytes
entity · KG edge: associated_with
Parkin (PARK2)
entity · KG edge: associated_with
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: associated_with

Knowledge Graph (12 edges)

PARKIN associated_with SYNJ1
LRRK2 associated_with SYNJ1
GAK associated_with SYNJ1
SYNJ1 associated_with DNAJC6
SYNJ1 associated_with PARK2
SYNJ1 associated_with VPS35
SYNJ1 associated_with PRKN
DNAJC6 associated_with SYNJ1
VPS35 associated_with SYNJ1
PRKN associated_with SYNJ1

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