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mechanism 1,170 words KG: ent-gene-36279336
Contents

SYNJ1→Synaptojanin-1→Synaptic Vesicle Recycling→PD Causal Chain

🔬 Protein Info
Gene Symbolent-gene-36279336
Presynaptic terminalsHighest concentration in the active zone
Dendritic spinesInvolved in postsynaptic endocytosis
perinuclear regionSecondary pool for protein turnover
KG Connections7 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

Wikipedia

Related Hypotheses (20)

SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.70Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67Vagal Afferent Microbial Signal Modulation
Score: 0.62Epigenetic Memory Reprogramming for Alzheimer's Disease
Score: 0.61Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54Vocal Cord Neuroplasticity Stimulation
Score: 0.52Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62Extracellular Vesicle Biogenesis Modulation
Score: 0.58Synaptic Vesicle Tau Capture Inhibition
Score: 0.58...
Score: 0.68APOE-Mediated Synaptic Lipid Raft Stabilization
Score: 0.65Complement-Mediated Synaptic Pruning Dysregulation
Score: 0.61Microglia-Derived Extracellular Vesicle Engineering for Targ
Score: 0.48

Related Analyses (30)

Synaptic pruning by microglia in early AD
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedSleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived

Knowledge Graph (7 edges)

32493451 is a substrate of ent-gene-36279336
32493451 is accumulated in ent-gene-36279336
32493451 correlates with ent-gene-36279336
32493451 is co-enriched with ent-gene-36279336
32493451 is critically involved in ent-gene-36279336
ent-gene-36279336 data_in benchmark_ot_ad_answer_key:SYNJ1
benchmark_ot_ad_answer_key:SYNJ1 data_in ent-gene-36279336

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