gene 826 words KG: SMAC
Contents

SMAC Gene

🧬 Gene Info
Gene SymbolSMAC
Full NameSecond Mitochondria-Derived Activator of Caspases
Chromosome12p12.31
FunctionMitochondrial release: Upon apoptotic stimuli, SMAC is released from mitochondrial intermembrane space
Molecular Weight29 kDa
Amino Acids239 aa
PathwaysApoptosis
UniProt IDQ9NR28
NCBI Gene ID56616
Ensembl IDENSG00000184047
OMIM605704
GeneCardsSMAC
Human Protein AtlasSMAC
Associated DiseasesGlioblastoma
InteractionsActin, AND, APOPTOSIS, ATM, ATR, AUTOPHAGY
KG Connections76 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (2)

CYP46A1 Overexpression Gene Therapy
Score: 0.95
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Apoptosis in Neurodegeneration
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
AIF Gene
gene · KG edge: regulates
ATM Gene
gene · KG edge: activates
ATR Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

UBIQUITIN interacts_with SMAC
DIABLO interacts_with SMAC
HTRA2 interacts_with SMAC
SMAC activates LC3
CD8 activates SMAC
E2F1 regulates SMAC
MYC regulates SMAC
DIABLO regulates SMAC
EGF regulates SMAC
ERK1 regulates SMAC

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