concept

TEMOZOLOMIDE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TEMOZOLOMIDE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

24Connections

0Hypotheses

0Analyses

12Outgoing

12Incoming

0Experiments

0Debates

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💡 Concept Info

Name	TEMOZOLOMIDE
Key Genes/Proteins	GPX4, SLC16A1, UBIQUITIN
Related Diseases	CELL DEATH, FERROPTOSIS, GLIOBLASTOMA, GLIOMA

Pathway Diagram

graph TD
    TEMOZOLOMIDE["TEMOZOLOMIDE"]
    TEMOZOLOMIDE -->|"treats"| glioblastoma["glioblastoma"]
    TEMOZOLOMIDE -->|"regulates"| miR_519a["miR-519a"]
    TEMOZOLOMIDE -->|"treats"| glioma["glioma"]
    TEMOZOLOMIDE -->|"inhibits"| GLIOBLASTOMA["GLIOBLASTOMA"]
    Ytx_7739["Ytx-7739"] -->|"interacts"| TEMOZOLOMIDE
    CBD["CBD"] -->|"interacts"| TEMOZOLOMIDE
    miR_519a -->|"regulates"| TEMOZOLOMIDE
    autophagy["autophagy"] -->|"interacts"| TEMOZOLOMIDE
    GPX4["GPX4"] -->|"activates"| TEMOZOLOMIDE
    SLC16A1["SLC16A1"] -->|"target for"| TEMOZOLOMIDE

Outgoing (12)

Target	Relation	Type	Str
glioblastoma	treats	disease	0.70
miR-519a	regulates	process	0.70
miR-519a	activates	process	0.70
glioma	treats	disease	0.70
GLIOBLASTOMA	inhibits	disease	0.65
GLIOBLASTOMA	associated_with	disease	0.65
FLUOXETINE	associated_with	drug	0.45
CELL DEATH	associated_with	phenotype	0.45
FERROPTOSIS	associated_with	phenotype	0.45
UBIQUITIN	associated_with	protein	0.45
GLIOMA	associated_with	disease	0.45
GPX4	associated_with	gene	0.45

Incoming (12)

Source	Relation	Type	Str
XHP	interacts_with	drug	0.85
Ytx-7739	interacts_with	drug	0.80
CBD	interacts_with	drug	0.70
miR-519a	regulates	process	0.70
autophagy	interacts_with	process	0.70
GPX4	activates	gene	0.65
SLC16A1	therapeutic_target	gene	0.60
FERROPTOSIS	associated_with	phenotype	0.45
GLIOBLASTOMA	associated_with	disease	0.45
GPX4	associated_with	gene	0.45
CELL DEATH	associated_with	phenotype	0.45
FLUOXETINE	associated_with	drug	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TEMOZOLOMIDE in their description or question text

No additional research found