Contents

SIGMAR1 Gene

🧬 Gene Info

Gene Symbol	SIGMAR1
Full Name	Sigma Non-Opioid Intracellular Receptor 1
Aliases	SIGMAR1 gene
Chromosome	9p13.3
Protein Type	Receptor
Function	Ligand binding: Small molecule agonists bind to the cytosolic domain, triggering conformational changes
Subcellular Localization	the endoplasmic reticulum (ER). The sigma-1 receptor plays critical roles in neuronal survival, calcium homeostasis, cel
Molecular Weight	25.3 kDa
Amino Acids	223 aa
Pathways	Blood-Brain Barrier, Toll-Like Receptor, apoptosis, inflammation
UniProt ID	Q9Y6D6
NCBI Gene ID	10280
Ensembl ID	ENSG00000147955
OMIM	608978
GeneCards	SIGMAR1
Human Protein Atlas	SIGMAR1
Associated Diseases	ALS, frontotemporal dementia, Inflammation, Lymphoma, Ms
Interactions	AND, ANXIETY, BCL-2, BCL2, Bdnf, BDNF
KG Connections	187 knowledge graph edges
Databases	GeneCards HPA STRING

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