protein

MERLIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MERLIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4Connections

0Hypotheses

0Analyses

3Outgoing

1Incoming

0Experiments

0Debates

Summary

Page for Merlin Protein

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🔬 Protein Info

Gene Symbol	MERLIN
Chromosome	22q12.2.
Function	Merlin Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Subcellular Localization	is tightly regulated ## Normal Function Merlin functions as a scaffold protein
Molecular Weight	70 kDa
Pathways	mTOR, mtor, MAPK, Notch signaling
GeneCards	MERLIN
Human Protein Atlas	MERLIN
ERM Protein Family	Ezrin, radixin, and moesin share structural homology and overlapping functions
NF2 Gene	Encodes merlin; germline mutations cause hereditary neurofibromatosis type 2
Hippo Pathway	YAP, TEAD, and other components regulated by merlin
Growth Factor Signaling	PI3K, AKT, MAPK, and receptor tyrosine kinases downstream of merlin regulation
Cytoskeletal Regulators	PAK, pp2A, and other kinases/phosphatases modulating merlin
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Merlin Protein

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Pathway Diagram

flowchart TD
    N0["merlin"]
    N1["PI3K/AKT"]
    N0 -->|"regulates"| N1
    N2["PI3K/AKT pathway"]
    N0 -->|"regulates"| N2
    N3["MAPK"]
    N0 -->|"regulates"| N3
    N4["NF2"]
    N4 -->|"encodes"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N1 pathway
    class N2 pathway
    class N3 pathway
    class N4 gene

Outgoing (3)

Target	Relation	Type	Str
PI3K/AKT	regulates	pathway	0.70
MAPK	regulates	pathway	0.70
PI3K/AKT pathway	regulates	pathway	0.70

Incoming (1)

Source	Relation	Type	Str
NF2	encodes	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MERLIN in their description or question text

No additional research found