gene

DDX20

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DDX20: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections

0Hypotheses

0Analyses

5Outgoing

3Incoming

0Experiments

0Debates

Summary

Comprehensive information about DDX20 (Gemin3), an RNA helicase in the SMN complex essential for snRNP biogenesis, with critical roles in ALS, spinal muscular atrophy, and RNA metabolism.

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🧬 Gene Info

Gene Symbol	DDX20
Full Name	DEAD-Box Helicase 20
Aliases	Gemin3
Chromosome	1p13.3
Function	is a member of the DEAD-box helicase family of RNA-binding proteins.
Gene Type	Protein-coding
Pathways	Autophagy, Proteasome
UniProt ID	Q9GZL0
NCBI Gene ID	112724
Ensembl ID	ENSG00000108465
GeneCards	DDX20
Human Protein Atlas	DDX20
Associated Diseases	ALS
KG Connections	8 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DDX20 — AlphaFold Q9GZL0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DDX20 Gene (DEAD-Box Helicase 20 / Gemin3)

gene · 1600 words

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DDX20 Protein

protein · 635 words

→

Pathway Diagram

graph TD
    DDX20["DDX20"]
    Ms{"Ms"}
    DDX20 -->|"interacts with"| Ms
    AUTOPHAGY["AUTOPHAGY"]
    DDX20 -->|"regulates"| AUTOPHAGY
    Proteasome(["Proteasome"])
    DDX20 -->|"regulates"| Proteasome
    Autophagy(["Autophagy"])
    DDX20 -->|"regulates"| Autophagy
    Immune_Response(["Immune Response"])
    DDX20 -->|"interacts with"| Immune_Response
    neurodegeneration["neurodegeneration"]
    DDX20 -->|"implicated in"| neurodegeneration
    PSMA3["PSMA3"]
    PSMA3 -->|"regulates"| DDX20
    PSMC1["PSMC1"]
    PSMC1 -->|"regulates"| DDX20
    AMBRA1["AMBRA1"]
    AMBRA1 -->|"regulates"| DDX20
    style DDX20 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (5)

Target	Relation	Type	Str
Ms	interacts_with	disease	0.65
AUTOPHAGY	regulates	gene	0.60
Proteasome	regulates	pathway	0.60
Autophagy	regulates	pathway	0.60
Immune Response	interacts_with	pathway	0.60

Incoming (3)

Source	Relation	Type	Str
PSMA3	regulates	gene	0.60
PSMC1	regulates	gene	0.60
AMBRA1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DDX20 in their description or question text

No additional research found